|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population.
|
29211635 |
2018 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma.
|
23841068 |
2013 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
rs1295686
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs1295686
|
|
T |
0.840 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs1295686
|
|
T |
0.840 |
GeneticVariation |
GWASCAT |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs20541
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results support the existence of a significant association between GSTP1 rs1695 and IL13 rs20541 SNPs, with susceptibility to asthma, in the population studied.
|
27561723 |
2018 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population.
|
29211635 |
2018 |
|
rs20541
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Self-Reported Allergic Rhinitis and/or Allergic Conjunctivitis Associate with IL13 rs20541 Polymorphism in Finnish Adult Asthma Patients.
|
28273659 |
2017 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
ICSNPathway analysis identified four candidate causal SNPs, four genes, and 21 candidate causal pathways, which in total provided four hypothetical biologic mechanisms: (1) rs7192 (nonsynonymous coding) to HLA-DRA to 21 pathways, such as, the role of eosinophils in the chemokine network of allergy, Th1/Th2 differentiation, and asthma (nominal p ≤ 0.001, FDR p ≤ 0.01); (2) rs20541 (nonsynonymous coding) to IL13 to asthma and cytokines and inflammatory response (nominal p<0.001, FDR p ≤ 0.008); (3) rs1058808 (frameshift coding) to ERBB2 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01); (4) rs17350764 (nonsynonymous coding (deleterious)) to OR52J3 to transmembrane receptor activity (nominal p=0.001, FDR p=0.01).
|
23200760 |
2013 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10(-9)), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear.
|
22286212 |
2012 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To investigate associations between total serum immunoglobulin E (IgE) levels and single nucleotide polymorphisms (SNPs) from eight candidate genes (IL-4 rs2243250, IL-4Rα rs1805010, IL-13 rs20541, IL-13Rα1 rs2495636, CD14 rs2569190, tumor necrosis factor-alpha (TNF-α) rs1800629, cytotoxic T lymphocyte-associated antigen (CTLA4) rs231775, FCER1B rs1441585) in children with asthma and to evaluate gene-gene interactions.
|
22376040 |
2012 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses.
|
22222605 |
2012 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The minor allele T of rs20541 in IL13 is the risk allele for asthma but the protective allele for psoriasis.
|
22694930 |
2012 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the present study, we confirmed the association of rs1800469 in TGF-beta1 and rs20541 in IL-13 with asthma and found a trend toward association between rs2241712 in TGF-beta1 and rs2070874 in IL-4 with asthma among atopic subjects, suggesting TGF-beta1, IL-4 and IL-13 may be associated with the susceptibility and development of asthma in this Chinese population.
|
22053598 |
2011 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations.
|
20484924 |
2010 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We show that IL13 rs20541 and rs1800925 are each significantly associated with self-reported asthma and allergy, and that this association is not confounded by any of the known developmental and environmental risk factors for asthma and atopy, including in particular place of birth.
|
19254294 |
2009 |
|
rs20541
|
|
|
0.800 |
GeneticVariation |
BEFREE |
IL13 encodes IL-13, a Th2 cytokine, and rs1800925 and rs20541 confer risk of asthma.
|
19554022 |
2009 |
|
rs115008099
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
|
rs1800925
|
|
|
0.090 |
GeneticVariation |
BEFREE |
On the other hand, the minor A alleles for rs762534 and rs1800925 were not significantly associated with asthma risk.
|
29211635 |
2018 |
|
rs1800925
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |