Gene: TSLP ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3806932
rs3806932
TSLP
0.720 GeneticVariation BEFREE Two SNPs, rs1544791 (PDE4D) and rs3806932 (TSLP), were more strongly associated with the high smoking history subgroup than with asthma or any other subgroups. 27058054

2016
dbSNP: rs3806932
rs3806932
TSLP
0.720 GeneticVariation BEFREE For TSLP-WDR36 region, rs3806932 (G allele protective against eosinophilic esophagitis) and rs2416257 (A allele associated with lower eosinophil counts and protective against asthma) were correlated with decreased expression of TSLP in BAL (P = 7.9 × 10(-11) and 5.4 × 10(-4) , respectively) and BEC, but not WDR36. 26119467

2015
dbSNP: rs3806932
rs3806932
TSLP
0.720 GeneticVariation GWASDB Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. 21907864

2011
dbSNP: rs1898671
rs1898671
TSLP
T 0.710 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738

2019
dbSNP: rs1898671
rs1898671
TSLP
0.710 GeneticVariation BEFREE Haplotype-specific score test indicated that an elevated risk for asthma was associated with a specific haplotype of TSLP involving SNP rs1898671 (OR = 1.58, 95% CI: 1.10-2.27, p = 0.01). 21966427

2011
dbSNP: rs10455025
rs10455025
TSLP
C 0.700 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806

2018
dbSNP: rs2289276
rs2289276
TSLP
0.030 GeneticVariation BEFREE The presence of allergic rhinitis in asthmatic children strengthened the association of the rs11466749 GG genotype with asthma (p = 0.001), and rs2289276 was significantly associated with lower FEV1 levels in asthmatics without allergic rhinitis (p = 0.003). 24525665

2014
dbSNP: rs2289276
rs2289276
TSLP
0.030 GeneticVariation BEFREE We found that the promoter polymorphisms rs3806933 and rs2289276 were significantly associated with disease susceptibility in both childhood atopic and adult asthma. 20656951

2011
dbSNP: rs2289276
rs2289276
TSLP
0.030 GeneticVariation BEFREE Two SNPs in TSLP (rs1837253 and rs2289</span>276) were significantly associated with a reduced risk of a</span>sthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). 20560908

2010
dbSNP: rs3806933
rs3806933
TSLP
0.020 GeneticVariation BEFREE Two functional SNPs showed a gender-specific association with allergy, i.e. the rs3806933 CC genotype with asthma in boys (p = 0.032, nonsignificant after multiple testing) and the rs2289276 CC genotype with higher eosinophil numbers in asthmatic girls (p = 0.003). 24525665

2014
dbSNP: rs3806933
rs3806933
TSLP
0.020 GeneticVariation BEFREE The functional SNP rs3806933 was associated with a</span>sthma (meta-analysis, P = 0.000056; odds ratio, 1.29; 95% confidence interval, 1.14-1.47). 20656951

2011
dbSNP: rs2289278
rs2289278
TSLP
0.010 GeneticVariation BEFREE In subjects with AD, the rs2289278 C allele also significantly increased the risk of developing asthma (odds ratio 8.31, 95% confidence interval 1.08-64.13). 26712523

2016
dbSNP: rs11466749
rs11466749
TSLP
0.010 GeneticVariation BEFREE The presence of allergic rhinitis in asthmatic children strengthened the association of the rs11466749 GG genotype with asthma (p = 0.001), and rs2289276 was significantly associated with lower FEV1 levels in asthmatics without allergic rhinitis (p = 0.003). 24525665

2014