|
rs8076131
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Doctor-diagnosed asthma was associated with common risk alleles for early onset asthma at gene locus 17q21 (P = .01 for rs8069176; P = .03 for rs8076131), and higher airways resistance (P = .02) and FENO levels (P = .03).
|
29524536 |
2018 |
|
rs12603332
|
|
|
0.730 |
GeneticVariation |
BEFREE |
rs12603332 is associated with male asthma patients specifically in urban areas of Lahore, Pakistan.
|
28055272 |
2017 |
|
rs8076131
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Within 17q12-21, only the tag SNP rs8076131 was significantly associated with asthma (P = 8.53 × 10(-10); odds ratio, 0.6715), and AR status was independent of SNPs in this region.
|
26483175 |
2016 |
|
rs8076131
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Early wheeze was positively associated with presence of older siblings among carriers of known asthma risk alleles at 17q21 (e.g., rs8076131) (adjusted odds ratio [aOR], 1.53; 95% confidence interval [CI], 1.16-2.01).
|
26575599 |
2016 |
|
rs12603332
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Besides, linear regression analysis showed that rs3894194 and rs12603332 were also significantly associated with asthma phenotypes such as log10 -transformed immunoglobulin E (IgE) level (IU/ml) and log10 -transformed eosinophil percentage (dominant, P=0.04; additive, P=0.01; recessive, P=0.04; recessive, P=0.03; additive, P=0.02).
|
24649901 |
2014 |
|
rs12603332
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs8076131
|
|
|
0.730 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs12603332
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We found significant associations between two SNPs within ORMDL3 (rs4378650 and rs12603332) and asthma in Mexicans and African Americans (P = 0.028 and 0.001 for rs4378650 and P = 0.021 and 0.001 for rs12603332, respectively), and a trend toward association in Puerto Ricans (P = 0.076 and 0.080 for SNPs rs4378650 and rs12603332, respectively).
|
18310477 |
2008 |
|
rs4795403
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs4378650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Individuals carrying the C allele of rs4378650 or the T allele of rs7216389 had increased risk of asthma [relative risk (RR) = 1.73, 95% confidence interval (CI) 1.19-2.53, P = 0.003 for one or two copies of rs4378650 C, and RR = 1.64, 95% CI 1.12-2.38, P = 0.009 for one or two copies of rs7216389 T).
|
19133921 |
2009 |
|
rs4378650
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found significant associations between two SNPs within ORMDL3 (rs4378650 and rs12603332) and asthma in Mexicans and African Americans (P = 0.028 and 0.001 for rs4378650 and P = 0.021 and 0.001 for rs12603332, respectively), and a trend toward association in Puerto Ricans (P = 0.076 and 0.080 for SNPs rs4378650 and rs12603332, respectively).
|
18310477 |
2008 |
|
rs4065275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20).
|
22732088 |
2012 |
|
rs4795404
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significant interaction between 5 SNPs and smoking on AHR, and 3 interacted with smoking in relation to asthma with AHR (rs4795404, rs4795408, rs3859192).
|
22626592 |
2012 |
|
rs3169572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The single locus analysis showed only a borderline association between rs3169572 variant and asthma (p = 0.030, p(corr) > 0.05).
|
21843571 |
2011 |