rs2431689
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs17057846, rs1582417, and rs2431689 polymorphisms were associated with prognosis of astrocytoma, and rs1582417, rs17057846, and rs58747524 variants were associated with the survival rate in patients with low-grade glioma (I to II).
|
31513017 |
2020 |
rs12594
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox regression analysis shows that RYR2 rs12594 AA genotype and AG genotype were associated with OS of astrocytoma (AG genotype: HR = 1.62, 95% CI 1.04-2.53, p = 0.034; AA genotype: HR = 1.70, 95% CI 1.08-2.68, p = 0.021).
|
31440994 |
2019 |
rs16835904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis shows that RYR2 rs16835904 TC-TT genotype facilitated the risk of astrocytoma in male (OR = 1.93, 95% CI 1.15-3.24, p = 0.011).
|
31440994 |
2019 |
rs17522122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma.
|
31759389 |
2019 |
rs2378456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In recessive model, the patients with LPP rs2378456 CC genotype increased the risk of astrocytoma (OR = 1.43, 95% CI 1.01-2.02, p = 0.042).
|
31440994 |
2019 |
rs4261436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma.
|
31759389 |
2019 |
rs7115578
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs7115578 AG genotype represented a poorer prognosis of glioma (HR = 1.24, P=0.033) and astrocytoma (log-rank P=0.037, HR = 1.31, P=0.036).
|
31652449 |
2019 |
rs5050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma.
|
30383794 |
2018 |
rs1040177874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma.
|
27460417 |
2016 |
rs1801275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis showed that IL4R rs1801275 was significantly associated with overall survival of glioma and astrocytoma</span> patients (P < 0.05).
|
27495027 |
2016 |
rs1870377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, individuals with mutant allele A and genotype TA + AA of rs1870377 showed a protective effect against astrocytomas.
|
26081139 |
2016 |
rs2071559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers.
|
26081139 |
2016 |
rs2271338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-variant ADHD risk haplotype in evolutionary conserved region 47, formed by rs17226398, rs56038622, and rs2271338, reduced enhancer activity by 40% in neuroblastoma and astrocytoma cells (p<sub>Bonferroni</sub> < .0001).
|
27692237 |
2016 |
rs2305948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meanwhile, stratified analysis demonstrated that mutation of rs2071559 and rs2305948 could elevate the risk of astrocytomas more significantly in the subgroup of smokers than the nonsmokers.
|
26081139 |
2016 |
rs55819519
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry.
|
26990854 |
2016 |
rs9288516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP (rs9288516) in XRCC5 (HR: 1.69, 95%CI: 1.04 - 2.77, p = 0.049), surgical approach (HR: 0.61, 95%CI: 0.43 - 0.88, p = 0.003) and chemotherapy (HR: 0.71, 95%CI: 0.50 - 0.99, p = 0.029) were associated with astrocytoma prognosis.
|
27852033 |
2016 |
rs4809324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the stratified analyses showed a decreased risk of astrocytoma associated with RTEL1 rs6089953, rs6010620 and rs2297440 (p trend = 0.022, p trend = 0.042, p trend = 0.029, respectively) as well as an increased risk of this subtype associated with RTEL1 rs4809324 (p trend = 0.033).
|
26014354 |
2015 |
rs6089953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the stratified analyses showed a decreased risk of astrocytoma associated with RTEL1 rs6089953, rs6010620 and rs2297440 (p trend = 0.022, p trend = 0.042, p trend = 0.029, respectively) as well as an increased risk of this subtype associated with RTEL1 rs4809324 (p trend = 0.033).
|
26014354 |
2015 |
rs71305152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the astrocytoma subtype, higher ZFPM2 expression was also correlated with the rs71305152 heterozygous genotype (P = 0.028).
|
26207917 |
2015 |
rs3745601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated receptor functionality of the P2Y11 A87T mutant using HEK293 and 1321N1 astrocytoma cells.
|
24524250 |
2014 |
rs137852972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we show that expression of seipin N-glycosylation mutant N88S led to decreased triglyceride (TG) content in astrocytoma and motor neuron cell lines.
|
23250914 |
2013 |
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
rs6010620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
rs58064122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP).
|
22705585 |
2012 |
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We suggest that XRCC3 Thr241Met polymorphism is involved in susceptibility for developing astrocytomas and glioblastomas.
|
22370935 |
2012 |