Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels. 23247802

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Relationships between IC- or EC atherosclerosis and plasma tHcyt level and/or MTHFR 677C>T genotypes were analyzed after adjusting for vascular risk factors. 20825473

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. 19398669

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital. 19403988

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study. 17934972

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The severe atheromatosis group showed rates of 62.0% and 6.9% for the C677T MTHFR gene polymorphism, in heterozygous and homozygous subjects, respectively. 17384833

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We measured plasma high-sensitive C-reactive protein (hs-CRP) levels and screened for the C677T polymorphism of the 5-10 methylenetetrahydrofolate reductase gene (MTHFR), which is considered a genetic risk factor for atherosclerosis, by HinfI digestion. 15764293

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This study aimed at assessing the effect of folic acid supplementation quantitatively in each MTHFR C677T genotype and considered the efficiency of tailor-made prevention of atherosclerosis. 15895286

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease. 16274479

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The guanine to thymine polymorphism at position 894 of the eNOS gene (resulting in a change from glutamate to aspartate [Asp] at codon 298 [Asp298]) and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism (C677T) have been reported to be associated with atherosclerosis and cardiovascular disease. 15494775

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The aim of this study was to investigate the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) mutation in healthy Croatian volunteers and in patients with atherosclerosis. 12927690

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Hyperhomocysteinaemia, a risk factor for atherosclerosis, is common in dialysis patients and particularly in those homozygous for a common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T transition). 11865092

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE High plasma homocysteine, a risk factor for atherosclerosis, is frequently caused by a common mutation in the gene for the enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR), C677T (alanine to valine substitution) or low intake of B vitamins that affect the remethylation or transsulfuration pathways in homocysteine metabolism. 12204804

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with reduced enzyme activity, hyperhomocysteinaemia and increased risk for atherosclerosis in homozygotes. 11094304

2000