|
rs10842262
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs12097821
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs2477686
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs6080550
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.
|
22197933 |
2011 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Meta-analysis revealed an association by use of fixed-effects model of MTHFR C677T with the risk of azoospermia.
|
24268703 |
2014 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population.
|
26549413 |
2015 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Influence of methylenetetrahydrofolate reductase C677T gene polymorphisms in Algerian infertile men with azoospermia or severe oligozoospermia.
|
22928696 |
2012 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia.
|
16888682 |
2007 |
|
rs1217691063
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis is in favor that the MTHFR C677T polymorphism is capable of causing male infertility susceptibility, especially in Asians and the subgroup of azoospermia.
|
26584688 |
2016 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing.
|
25908656 |
2015 |
|
rs12870438
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, the polymorphic distributions of three common polymorphism loci including T-786C, 4A4B and G894T in eNOS gene were investigated in 355 Chinese infertile patients with azoospermia or oligozoospermia and 246 healthy fertile men and a meta-analysis was carried in order to explore the possible relationship between the three loci of eNOS gene and male infertility with spermatogenesis impairment.
|
23756085 |
2013 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the possible association of three genetic variants (rs2070744, rs1799983 and intron variant 4a/4b) in NOS3 gene and infertility occurrence in two groups of infertile men (idiopathic azoospermia and oligoasthenozoospermia) and fertile controls.
|
28466478 |
2018 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs2075789
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia.
|
19808033 |
2010 |
|
rs25487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a selected Chinese population, AA genotype of Arg399Gln appears to contribute to a decreased risk of idiopathic azoospermia, while we have not any evidence of involvement of XRCC1 T-77C and Arg194Trp polymorphisms in idiopathic azoospermia.
|
17968463 |
2007 |
|
rs25487
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the SNP locus rs25487 of XRCC1 could be a marker for genetic susceptibility to idiopathic azoospermia and the A allele might be a risk gene of idiopathic azoospermia in the northern Chinese Han population.
|
22868082 |
2012 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Pooled estimate on c.1298A>C data from all published studies including our data showed no association of this polymorphism with male infertility (Odds ratio = 1.035, P = 0.56), azoospermia (Odds ratio = 0.97, P = 0.74), or oligoasthenoteratozoospermia (Odds ratio = 0.92, p = 0.29).
|
23874907 |
2013 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis supports that the MTHFR A1298C polymorphism is capable of causing male infertility susceptibility, especially azoospermia.
|
22175540 |
2012 |
|
rs7174015
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of these, three SNPs (rs7867029, rs7174015, and rs12870438) were found to be significantly associated with the risk of azoospermia and/or oligozoospermia in a Japanese population.
|
28975488 |
2018 |
|
rs7174015
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The association between rs7174015 and oligozoospermia under a dominant model and between rs12870438 and azoospermia under additive and recessive models remained after correction for multiple testing.
|
25908656 |
2015 |
|
rs10129954
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, a statistically significant association between rs10129954 and azoospermia, and oligozoospermia was observed.
|
28975488 |
2018 |
|
rs10269148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic variant rs10269148 of STRA8 gene showed higher risk of spermatogenic impairment in the groups of abnormospermia (including azoospermia subgroup and oligozoospermia subgroup) and azoospermia than the controls with odds ratios and 95% confidence intervals of 2.52 (1.29-4.94) and 2.92 (1.41-6.06), respectively (P = 0.006, 0.002 respective).
|
23320086 |
2013 |
|
rs1059060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One intronic SNP in MLH1 (rs4647269) and two non-synonymous SNPs in PMS2 (rs1059060, Ser775Asn) and MSH5 (rs2075789, Pro29Ser) seem to be risk factors for the development of azoospermia or oligozoospermia.
|
22594646 |
2012 |
|
rs11204546
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Clinically, the SNPs (rs11204546 of OR2W3 and rs11677854 of GTF2A1L ) might be additional valuable molecular predictive markers for assessing the treatment of NOA patients.
|
25374392 |
2015 |