|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Of these 5 loci, 2 were found to be significantly associated with BD susceptibility: rs17375018 (G vs. A, OR = 1.50, 95% CI: 1.34-1.68, <i>P</i> < .00001) and rs924080 (T vs. C, OR = 1.36, 95% CI: 1.29-1.43, <i>P</i> < .00001).
|
31814470 |
2019 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
SNPs (rs924080 and rs11209032) of the IL23R-IL12RB2 region were found to be associated with BD in a Northern Chinese Han population.
|
27660093 |
2016 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs924080
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Six SNPs in IL23R-IL12RB2 were found to be associated with BD after Bonferroni correction for multiple testing, the most significant of which were rs17375018 (OR for G allele 1.51, 95% CI 1.27-1.78, P(unadj) = 1.93 × 10(-6) ), rs7517847 (OR for T allele 1.48, 95% CI 1.26-1.74, P(unadj) = 1.23 × 10(-6) ), and rs924080 (OR for T allele 1.29, 95% CI 1.20-1.39, P = 1.78 × 10(-5) ).
|
22378604 |
2012 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Similarly, rs1518111, which showed strong linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Interestingly, we have found, majority of the tribal populations have low frequency of VL ('A' of rs3024498); and high frequency of leprosy ('T' of rs1554286), and Behcet's ('A' of rs1518111) associated alleles, whereas these were vice versa in castes.
|
25941808 |
2015 |
|
rs1518111
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ).
|
22378604 |
2012 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Similarly, rs1518111, which showed strong</span> linkage disequilibrium (r(2)=1) with allele rs1800871, was also associated with BD (pc=0.026).
|
24269690 |
2014 |
|
rs1800871
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Compared to the controls, an increased frequency of the rs1800871 T allele was observed in BD patients with extraocular findings, including genital ulcers, skin lesions, and a positive pathergy test.
|
26015771 |
2015 |
|
rs1495965
|
|
|
0.820 |
GeneticVariation |
BEFREE |
SNPs rs10489629, rs1343151, and rs1495965 were also significantly associated with BD in all tests performed.
|
22378604 |
2012 |
|
rs1495965
|
|
|
0.820 |
GeneticVariation |
BEFREE |
An IL23R-IL12RB2 intergenic SNP rs1495965 was significantly associated with BD risk (OR (95% CI) = 1.5 (1.3, 1.7), P = 2.5 × 10<sup>-7</sup>) in the pooled meta-analysis of the discovery (1.4 (1.2, 1.7), P = 4.9 × 10<sup>-7</sup>) and replication (1.9 (1.3, 2.6), P = 6.0 × 10<sup>-4</sup>) phases.
|
29017598 |
2017 |
|
rs17482078
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Our aim was, the replication in the Spanish population of the association described in the Turkish population between ERAP1 (rs17482078) and BD.
|
25019531 |
2014 |
|
rs17482078
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Although preliminary, our data show a stronger association of rs17482078 with BS compa</span>red to rs27044 by means of case-control genetic analysis and bioinformatics prediction of protein structure change.
|
30820838 |
2019 |
|
rs2617170
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Significantly increased frequencies of the A allele as well as AA genotype of rs1800450 in MBL2 (Pc = 2.50 × 10<sup>-6</sup>, OR = 1.494; Pc = 2.24 × 10<sup>-6</sup>,OR = 2.899; respectively) and TT genotype of rs2617170 in KLRC4 (Pc = 2.53 × 10<sup>-6</sup>, OR = 1.695) and decreased frequencies of GG genotype of rs1800450 (Pc = 1.56 × 10-3, OR = 0.689) and C allele as well as CC genotype of rs2617170 (Pc = 2.05 × 10-9,OR = 0.664; Pc = 1.20 × 10-5, OR = 0.585; respectively) were observed in BD.
|
28706259 |
2017 |
|
rs2617170
|
|
|
0.820 |
GeneticVariation |
BEFREE |
For all 6 SNPs tested by meta-analysis (Pmeta ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] for A allele 1.29 [95% confidence interval (95% CI) 1.21-1.37], Pmeta = 2.34 × 10(-16) ; for rs7616215, OR for C allele 0.70 [95% CI 0.65-0.76], Pmeta = 1.54 × 10(-19) ; for rs17810546, OR for A allele 0.60 [95% CI 0.52-0.70], Pmeta = 6.34 × 10(-11) ; for rs2617170, OR for T allele 0.76 [95% CI 0.70-0.81], Pmeta = 2.75 × 10(-14) ; for rs13154629, OR for TT genotype 2.76 [95% CI 2.01-3.80], Pmeta = 3.57 × 10(-10) ).
|
26097239 |
2015 |
|
rs17810546
|
|
|
0.810 |
GeneticVariation |
BEFREE |
For all 6 SNPs tested by meta-analysis (Pmeta ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] for A allele 1.29 [95% confidence interval (95% CI) 1.21-1.37], Pmeta = 2.34 × 10(-16) ; for rs7616215, OR for C allele 0.70 [95% CI 0.65-0.76], Pmeta = 1.54 × 10(-19) ; for rs17810546, OR for A allele 0.60 [95% CI 0.52-0.70], Pmeta = 6.34 × 10(-11) ; for rs2617170, OR for T allele 0.76 [95% CI 0.70-0.81], Pmeta = 2.75 × 10(-14) ; for rs13154629, OR for TT genotype 2.76 [95% CI 2.01-3.80], Pmeta = 3.57 × 10(-10) ).
|
26097239 |
2015 |
|
rs7574070
|
|
|
0.810 |
GeneticVariation |
BEFREE |
For all 6 SNPs tested by meta-analysis (Pmeta ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] for A allele 1.29 [95% confidence interval (95% CI) 1.21-1.37], Pmeta = 2.34 × 10(-16) ; for rs7616215, OR for C allele 0.70 [95% CI 0.65-0.76], Pmeta = 1.54 × 10(-19) ; for rs17810546, OR for A allele 0.60 [95% CI 0.52-0.70], Pmeta = 6.34 × 10(-11) ; for rs2617170, OR for T allele 0.76 [95% CI 0.70-0.81], Pmeta = 2.75 × 10(-14) ; for rs13154629, OR for TT genotype 2.76 [95% CI 2.01-3.80], Pmeta = 3.57 × 10(-10) ).
|
26097239 |
2015 |
|
rs7616215
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Six SNPs (in decreasing order of significance, rs7616215 located 38 kb downstream of CCR1, rs2617170 [p.Asn104Ser] in KLRC4, rs17810546 in IL12A-AS1, rs7574070 in STAT4, and rs10050860 [p.Asp575Asn] and rs13154629 in ERAP1) were nominally associated with BD in both allelic association tests (5.05 × 10(-9) ≤ Pallele ≤ 7.55 × 10(-3) ) and sex-adjusted genotypic association tests (6.01 × 10(-9) ≤ adjusted P value ≤ 1.30 × 10(-2) ).
|
26097239 |
2015 |
|
rs1608157
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We found a novel association of BD to the GIMAP locus, mapped to chromosome 7q36.1 (rs1608157, p=6.01×10(-8) in a minor allele dominant model; rs11769828, allele based p=1.60×10(-6)).
|
23041938 |
2013 |
|
rs3024490
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To investigate the possible genetic factor for the elevation of plasma Hcy level in patients with BD by examining gene interaction with the MTHFR C677T polymorphism, a crucial factor of the Hcy metabolism.
|
16299146 |
2005 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and variations of homocysteine concentrations in patients with Behcet's disease.
|
23827456 |
2013 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association between thiolactonase (HTLase) activity and plasma homocysteine levels (tHcy) in a BD population and to investigate their association with methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype.
|
18076365 |
2008 |
|
rs1217691063
|
|
|
0.090 |
GeneticVariation |
BEFREE |
MTHFR gene C677T mutation does not increase risk of DVT in BD either alone or combined with FV Leiden mutation.
|
11128675 |
2000 |