Though we failed to replicate the individual association of rs10509906 to disease, the intragenic epistatic effect between rs10509906 and rs2501577 was suggested as exhibiting susceptibility to BA, further cross-validated by multifactor dimensionality reduction (MDR) (<i>P</i>=0.068, OR = 1.37), which may explain extra hidden heritability of <i>ADD3</i> to BA.
Two SNPs in <i>ADD3</i> were replicated as associated with BA (1.60E-04 ≤ <i>P</i>≤1.70E-04, 1.33 ≤ odds ratio (OR) ≤ 1.58 for rs17095355, 2.10E-04 ≤ <i>P</i>≤5.30E-04, 1.26 ≤ OR ≤ 1.57 for rs2501577</span>).
This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA.