Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes. 30079586

2019

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Genotyping results indicated that rs1006737 in CACNA1C was significantly associated with BD, while rs10994336 or rs9804190 in ANK3 was not significant when examined individually. 29684488

2018

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the ZNF804A gene. 27790829

2017

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC)). 28398341

2017

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder. 27276213

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Our study further supports the association of SNP rs1006737 with BD-I and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in LD with these proxies, act independently to increase risk and ICDH in BD-I. 25843436

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology. 26048451

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder. 26541689

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity. 25976633

2015

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. 23979604

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder. 23404764

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing. 24411473

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants. 24108394

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Although we were not able to replicate findings of association between individual CACNA1C SNPs rs7297582 and rs1006737 and BP, we were able to replicate the GWAS signal reported for CACNA1C through a haplotype analysis that encompassed these previously reported significant SNPs. 23437964

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE A total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)]. 23406546

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder</span> (BD) and schizophrenia (SZ) pathology. 23437284

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075

2013

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Using three samples, including healthy controls, patients with SCZ, and patients currently in manic episodes of BP, this study tested the association between the SNP rs1006737 and spatial working memory as measured by an N-back task and a dot pattern expectancy (DPX) task. 22012475

2012

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions. 21292451

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653

2010