rs78311289
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
|
|
|
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.
|
28655970 |
2017 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression.All statistical tests were two-sided.
|
26374428 |
2015 |
rs798766
|
|
T |
0.770 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Three previously established bladder cancer risk-associated SNPs (rs798766 in TACC3, rs9642880 in MYC, and rs2294008 in PSCA) were genotyped in 1,210 bladder cancer patients and 1,008 control subjects in Shanghai, China.
|
24155119 |
2014 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In the meta-analysis, the reported risk allele for four SNPs were significantly associated with increased bladder cancer risk, including rs798766 on TACC3 at 4p16, rs9624880 on MYC at 8q24, rs2294008 on PSCA at 8q24, and rs2736100 on TERT at 5p15.
|
22711262 |
2013 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Our results suggest that rs798766 on 4p16.3 may contribute to bladder cancer susceptibility in a Chinese population and explains an additional 3.65% of population attributable risk for bladder cancer.
|
21459758 |
2011 |
rs798766
|
|
T |
0.770 |
GeneticVariation |
GWASDB |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
rs798766
|
|
T |
0.770 |
GeneticVariation |
GWASDB |
The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC.
|
20348956 |
2010 |
rs798766
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The T allele of rs798766 on 4p16.3 was found to associate with UBC (odds ratio = 1.24, P = 9.9 x 10(-12)). rs798766 is located in an intron of TACC3, 70 kb from FGFR3, which often harbors activating somatic mutations in low-grade, noninvasive UBC.
|
20348956 |
2010 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive.
|
26600535 |
2015 |
rs9642880
|
|
T |
0.760 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65.
|
24740636 |
2014 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Characterization of functional consequences of genetic variation in the discrete region including rs9642880 is needed to understand biological basis of this bladder cancer-specific 8q24 association in these racial/ethnic groups characterized by both high and low risk of bladder cancer.
|
21051319 |
2010 |
rs9642880
|
|
T |
0.760 |
GeneticVariation |
GWASDB |
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
|
20348956 |
2010 |
rs9642880
|
|
T |
0.760 |
GeneticVariation |
GWASDB |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our findings suggested that the rs9642880 G>T polymorphism on 8q24 was independently associated with the risk of bladder cancer in Chinese populations.
|
19369583 |
2009 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Recently, a genome-wide single nucleotide polymorphism association study has identified a sequence variant 30 kb upstream of the c-Myc gene (allele T of rs9642880) that confers susceptibility to bladder cancer.
|
19801959 |
2009 |
rs9642880
|
|
T |
0.760 |
GeneticVariation |
GWASDB |
No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers.
|
18794855 |
2008 |
rs9642880
|
|
|
0.760 |
GeneticVariation |
BEFREE |
No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers.
|
18794855 |
2008 |
rs710521
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Fine-mapping of the GWAS signal region led to the identification of twenty SNPs that showed a stronger association with bladder cancer risk than rs710521.
|
29956121 |
2018 |
rs710521
|
|
A |
0.740 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
rs710521
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Genome-wide association studies have confirmed association of TP63C/T rs710521, TERTC/T rs2736098, and SLC14A1C/T rs17674580 gene variants with susceptibility to bladder cancer (BC) in European and White population.
|
25218484 |
2014 |
rs710521
|
|
A |
0.740 |
GeneticVariation |
GWASDB |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
|
20972438 |
2010 |