|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Thus, it is evident from our study that Arg72Pro SNP is implicated in bladder cancer, and that the rare, proline-related allele is connected with higher susceptibility to bladder cancer.
|
21156242 |
2010 |
|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
P53 Arg72Pro polymorphism and bladder cancer risk--meta-analysis evidence for a link in Asians but not Caucasians.
|
22901221 |
2012 |
|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Subgroup analyses by ethnicity showed that TP53 Arg72Pro polymorphism contributed to bladder cancer</span> risk in East Asians in three genetic models (For Pro vs. Arg, Fixed-effects OR 1.18, 95 % CI 1.05-1.32; For ProPro vs. ArgArg, Fixed-effects OR 1.40, 95 % CI 1.11-1.77; For ProPro vs. ArgPro/ArgArg, Fixed-effects OR 1.32, 95 % CI 1.07-1.62).
|
23184052 |
2013 |
|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that p53 Arg72Pro polymorphism is associated with increased risk of bladder cancer in Asians.
|
23073555 |
2013 |
|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk.
|
20630574 |
2010 |
|
rs1131691014
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the susceptibility to bladder cancer.
|
19523860 |
2011 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test.
|
25767210 |
2015 |
|
rs1135612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we first sequenced all 16 POR exons among 50 randomly selected controls, and found three variants, rs1135612, rs1057868 (A503V) and rs2228104, which were then assessed the relation to risk of bladder cancer in a case-control study of 1,050 bladder cancer cases and 1,404 cancer-free controls in a Chinese population.
|
26123203 |
2015 |
|
rs1136410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using multifactor dimensionality reduction approach, the four-factor model, including smoking status, OGG1 S326C (rs1052133), APEX1 D148E (rs3136820), and ADPRT762 (rs1136410), had the best ability to predict bladder cancer risk with the highest cross-validation consistency (100%) and the lowest prediction error (37.02%; P < 0.001).
|
17220334 |
2007 |
|
rs1141718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The detoxifying enzymes inactivate dangerous chemical compounds and anions for the cell; that is, why it is important to know if the polymorphisms pro198leu in GPX-1 and ile58thr in MnSOD are associated with bladder cancer.
|
20441054 |
2010 |
|
rs11466445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution of the TGFBR1*6A allele (rs11466445) was also similar among cases and controls, indicating no association with bladder cancer risk.
|
19004027 |
2009 |
|
rs11543198
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs8041357, which is in complete linkage disequilibrium (r(2) = 1) with rs11543198, was also associated with bladder cancer risk in Europeans (P = 0.045 for an additive and P = 0.025 for a recessive model), despite much lower minor allele frequency in Europeans (3.7%) compared with the Japanese (22.2%).
|
25281661 |
2015 |
|
rs11614913
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found that CT (miR-196a2, C>T rs11614913) was a risk factor for renal cell carcinoma (CT vs. CC: OR = 1.72, 95%CI = 1.05-2.80, <i>P</i> = 0.03, <i>I</i><sup>2</sup> = 66%), especially in Asian population (CT vs. CC: OR = 1.17, 95%CI = 1.04-1.32, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%). miR-146a G>C rs2910164 was a protective factor of urological cancers (C vs. G: OR = 0.87, 95%CI = 0.81-0.93, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%), especially for bladder cancer. miR-499 A>G rs3746444 was correlated with an increased risk of urological cancers, specifically in Asian population.
|
28579964 |
2017 |
|
rs11614913
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Even though there was no association between the individuals carrying the variant genotypes of the three miRNA studied and bladder cancer risk, marginal significance of heterozygousity in rs11614913 suggested further characterization of miRNA SNPs in a large cohort of varied ethnicity.
|
21345130 |
2011 |
|
rs11614913
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results suggested hsa-mir-196a2 rs11614913 C/T is associated with a significantly decreased risk of bladder cancer and hsa-mir-146a rs2910164 GG genotype is associated with clinical stage and metastasis in bladder cancer.
|
26458899 |
2015 |
|
rs11614913
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Further, rs11614913 was found to be significantly associated with decreased cancer risk, in particular, for bladder cancer, gastric cancer, and SCCHN.
|
24278149 |
2013 |
|
rs11671784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study identified a causative relationship between rs11671784 G/A variation, lowered miR-27a expression, increased RUNX-1 expression and following weakened chemo-sensitivity. rs11671784 G allele has significantly stronger effect over A allele in promoting chemo-sensitivity in bladder cancer. miR-27a mediates chemotherapy at least partially through reducing P-gp expression and increasing apoptosis.
|
25656571 |
2015 |
|
rs11685387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this hospital-based case-control study, the association of Ku80 G-1401T rs828907, Ku80 C-319T rs11685387 and Ku80 intron 19 rs9288518 polymorphisms with bladder cancer risk in a central Taiwanese population was investigated.
|
19414375 |
2009 |
|
rs11871756
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four variants within ZIP11 were significantly associated with bladder cancer risk: rs11871756 (OR = 1.43, 95 % CI (1.24-1.63), p = 0.0002), rs11077654 (OR = 0.76, 95 % CI (0.68-0.85), p = 0.001), rs9913017 (OR = 0.76, 95 % CI (0.68-0.85), p = 0.002), and rs4969054 (OR = 0.78, 95 % CI (0.69-0.88), p = 0.02); the three protective variants were co-located and highly correlated.
|
25900876 |
2015 |
|
rs11892031
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (P interaction ≤ .001), rs11892031 (UGT1A, P interaction = .01), and rs798766 (TMEM129-TACC3-FGFR3, P interaction = .03).
|
26374428 |
2015 |
|
rs11892031
|
|
|
0.730 |
GeneticVariation |
GWASDB |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs11892031
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1.
|
20972438 |
2010 |
|
rs11892031
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population.
|
25347272 |
2014 |
|
rs11892031
|
|
A |
0.730 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies multiple loci associated with bladder cancer risk.
|
24163127 |
2014 |
|
rs1189516787
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The luciferase assays further showed that there was a point mutation (A231G) in the C/EBPα binding site of the lncRNA-UCA1 core promoter in various bladder cancer cell lines, which in turn significantly increased the transcriptional activity of lncRNA-UCA1.
|
24648007 |
2014 |