Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE The combined results based on all studies suggested that XRCC3 Thr241Met was associated with bladder cancer risk under homozygote and recessive models. 24085356

2014

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE In summary, this meta-analysis suggests the participation of XRCC3 T241M in the susceptibility for bladder cancer and breast cancer, especially in Caucasians, and XRCC3 T241M polymorphism is associated with decreased lung cancer risk. 23562721

2013

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE The study was designed to examine the polymorphisms associated with two genes namely XRCC4 G1394T (rs6869366), intron 3 (rs28360317), intron 7 rs1805377 and rs2836007 and XRCC3 (rs861539 and rs1799796), respectively and investigate their role as susceptible markers for UBC risk in North Indian cohort. 21617942

2012

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE DNA repair gene XRCC3 T241M polymorphism and bladder cancer risk in a Chinese population. 22299591

2012

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE Taken together, our meta-analysis had suggested an increased risk role of XRCC3 241MM genotype in bladder cancer among all subjects, and the effect of T241M polymorphism on bladder susceptibility should be studied with a larger, stratified population. 20947146

2011

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE We undertook a case-control study of 212 urothelial bladder cancer (UBC) cases and 250 controls to investigate the association between OGG1 (C1245G rs1052133), XRCC3 (C18067T, rs861539) and XRCC7 (G6721T, rs7003908) polymorphisms and bladder cancer susceptibility by PCR-RFLP and the ARMS method. 19815090

2010

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE In summary, our meta-analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer.(Cancer Sci 2010). 20500515

2010

dbSNP: rs861539
rs861539
0.080 GeneticVariation BEFREE Gene-environment interaction with arsenic exposure was observed in relation to bladder cancer risk for a variant allele of the double-strand break repair gene XRCC3 T241M (adjusted OR 2.8 (1.1-7.3)) comparing to homozygous wild type among those in the top arsenic exposure decile (interaction p-value 0.01). 19429237

2009