Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs118203347
rs118203347
0.700 GeneticVariation UNIPROT

dbSNP: rs118203385
rs118203385
0.700 GeneticVariation UNIPROT

dbSNP: rs1323541164
rs1323541164
0.700 GeneticVariation UNIPROT

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7). 30407486

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer. 31008939

2019

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. 28881685

2017

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs25487 and rs1799782) in XRCC1, and three SNPs (rs1799794, rs861531 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer. 27153553

2016

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216

2015

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Overall, seven of the 14 variants were significantly associated with bladder cancer risk (p = 9.763 × 10(-3) for rs9642880 at 8q24.21, p = 3.004 × 10(-3) for rs2294008 at 8q24.3, p = 0.012 for rs798766 at 4p16.3, p = 0.034 for rs1495741 at 8p22, p = 2.306 × 10(-4) for GSTM1, p = 8.507 × 10(-8) for rs17674580 at 18q12.3, p = 7.179 × 10(-4) for rs10936599 at 3q26.2) and the odds ratios (ORs) ranged from 1.13 to 1.65. 24740636

2014

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Our study showed that the rs2294008 polymorphism in the PSCA gene is associated with the risk of bladder cancer in a Korean population, providing evidence that it may contribute to bladder carcinogenesis regardless of ethnicity. 25374226

2014

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE In conclusion, the results suggest that the PSCA rs2294008 (C>T) polymorphism is a risk factor for bladder cancer development. 25117309

2014

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE We identified no association between the XRCC1 Arg399Gln polymorphism and bladder cancer risk. 25501209

2014

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE The analysis suggests that the XRCC1 Arg399Gln polymorphism might be a moderate risk factor for bladder cancer, especially in non-Asian population. 24176953

2014

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE The study suggests that anti-PSCA immunotherapy might be beneficial for bladder cancer patients with high tumor PSCA expression, which is statistically significantly associated with the presence of CT and TT genotypes of a common genetic variant, rs2294008. 23266392

2013

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE We conducted a meta-analysis to ascertain the association of XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms with bladder cancer risk in Asian population. 23704969

2013

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE The meta-analysis results suggest that XRCC1 Arg194Trp and Arg399Gln polymorphisms may be associated with elevated bladder cancer risk. 23496911

2013

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE This meta-analysis suggests that the XRCC1 R399Q polymorphism may play a protective role against bladder cancer among smokers. 24039945

2013

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE The overall data failed to indicate significant associations between XRCC1 A</span>rg399Gln polymorphism and bladder cancer risk (Gln/Gln versus Arg/Arg: odds ratio (OR) = 0.97; 95% CI = 0.85-1.10; dominant model: OR = 1.02; 95% CI = 0.94-1.09; recessive model: OR = 0.95; 95% CI = 0.84-1.07). 23479765

2013

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE Significant increased risk of bladder cancer was observed for Arg194Trp polymorphism (allele comparison OR = 1.20, 95 % CI: 1.06-1.36, P heterogeneity = 0.11; dominant model OR = 1.20, 95 % CI: 1.02-1.41, P heterogeneity = 0.37) and Arg280His polymorphism (heterozygote comparison OR = 1.87, 95 % CI: 1.21-2.90, P heterogeneity = 0.01; dominant model OR = 1.75, 95 % CI: 1.05-2.90, P heterogeneity = 0.01); however, Arg399Gln was not associated with susceptibility to bladder cancer. 23636799

2013

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE In conclusion, a joint effect of two PSCA SNPs, rs2294008 and rs2978974, suggests that both variants may be important for bladder cancer susceptibility, possibly through different mechanisms that influence the control of mRNA expression and interaction with regulatory factors. 22416122

2012

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. 22927776

2012

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE These results indicated that the rs2294008 pol</span>ymorphism of PSCA gene may play a role in bladder cancer carcinogenesis and it could be served as a biomarker for genetic susceptibility to bladder cancer in Chinese populations. 20083643

2010

dbSNP: rs2294008
rs2294008
PSCA ; JRK
0.100 GeneticVariation BEFREE Our data identify rs2294008 as a new bladder cancer susceptibility locus. 19648920

2009

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE No association was found between the polymorphisms in XRCC1 (Arg(194)Trp, Arg(280)His, Arg(399)Gln) and bladder cancer susceptibility. 18336890

2008

dbSNP: rs25487
rs25487
0.100 GeneticVariation BEFREE It indicated that XRCC1 R399Q and R194W might not be risk factors to bladder cancer, but the 399QQ genotype decreased susceptibility of bladder cancer under recessive model and homozygote contrast among ever-smokers. 18765423

2008