rs28934578
|
|
|
0.750 |
GeneticVariation |
BEFREE |
We found that zinc re-established chemosensitivity in breast cancer SKBR3 (expressing R175H mutation) and glioblastoma U373MG (expressing R273H mutation) cell lines.
|
21508668 |
2011 |
rs28934578
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Using the MMTV-ERBB2;mutant p53 (R175H) in vivo mouse model of ERBB2-positive breast cancer, together with mouse and human cell lines, we compared lapatinib-resistant vs. lapatinib-sensitive tumor cells biochemically and by kinome arrays and evaluated their viability in response to a variety of compounds affecting heat shock response.
|
29799521 |
2018 |
rs28934578
|
|
|
0.750 |
GeneticVariation |
BEFREE |
None of the intronic mutations has shown significant association with the breast cancer, two exonic mutations G13203A (rs28934578) and A14572G are significantly (P = 0.04, P = 0.007) associated with breast cancer.
|
24929325 |
2014 |
rs28934578
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Using the SKBR3 breast cancer and p53-null H1299 lung cancer cells stably expressing the R175H p53 mutant protein, we demonstrated that GON triggers the appearance of a wild-type-like p53 protein by using conformation-specific antibodies, immunoprecipitation, DNA-binding assays and target gene expression. p53 restoration was associated with a G2/M arrest, senescence, reduced cell migration, invasion and increased cell death.
|
30010803 |
2018 |
rs28934578
|
|
|
0.750 |
GeneticVariation |
BEFREE |
These findings provide the basis for R175H to promote the initiation of breast cancer by expanding MESCs.
|
22824795 |
2013 |
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We found that zinc re-established chemosensitivity in breast cancer SKBR3 (expressing R175H mutation) and glioblastoma U373MG (expressing R273H mutation) cell lines.
|
21508668 |
2011 |
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Mutation R273H confers p53 a stimulating effect on the IGF-1R-AKT pathway via miR-30a suppression in breast cancer.
|
26898459 |
2016 |
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Expression of mutant p53 (mtp53) R273H associates with increased cell elasticity, survival under serum deprivation conditions, and increased Poly (ADP ribose) polymerase 1 (PARP1) on the chromatin in the AA-derived TNBC breast cancer cell line MDA-MB-468.
|
26703669 |
2015 |
rs28934576
|
|
|
0.740 |
GeneticVariation |
BEFREE |
These results indicate that mtp53 R273H and PARP1 interact with replicating DNA and should be considered as dual biomarkers for identifying breast cancers that may respond to combination PARPi treatments.
|
31776133 |
2020 |
rs11540652
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient.
|
26703669 |
2015 |
rs11540652
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The R248Q mutant co-localized with amyloid-like species in a breast cancer sample, which further supported its prion-like effect.
|
22715097 |
2012 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.
|
30065615 |
2018 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was undertaken to investigate the association of p53 Arg72Pro, Ins16bp and G13964C polymorphisms and their haplotypes with breast cancer risk in Tunisian women.
|
20233677 |
2010 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five single nucleotide polymorphisms (SNPs) in PRKAG2 (rs1029946, rs4726050, rs6464153, rs7789699) and PPP2R2B (rs10477313) for 10-year survival in breast cancer patients, interaction with TP53 R72P and MDM2-SNP309, outcome after specific adjuvant therapy and correlation to tumor characteristics in 4,701 invasive cases from four data sets.
|
23034890 |
2013 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that TP53 c.215G>C, p. (Arg72Pro) polymorphism may be considered as a genetic marker for predisposition to BC in Moroccan population.
|
29949804 |
2018 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of double heterozygotes (P187S/R72P) of the NQO1 and TP53 genes (OR=1.88; 95% CI 1.13-3.15; P=0.011), suggesting a possible interaction of these two loci.
|
15138483 |
2004 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in breast cancer: predisposition and survival.
|
23716179 |
2013 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we investigated whether MDM2-SNP309 is associated with p53 R72P genetic polymorphism for the risk of breast cancer development in Asian Taiwanese, which has not been well-studied in this regard.
|
21479369 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our finding suggests that TP53 (Arg72Pro) polymorphism may play a significant role as risk factor for breast cancer in north Indian breast cancer patients.
|
26553387 |
2016 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
550 samples (275 cases/275 control) of peripheral blood obtained from women (aged 22-87 years) with breast cancer and from healthy women (aged 23-87 years) were genotyped for frequencies of the following gene variances: R72P/rs1042522 (gene TP53) and S31R/ss4388499 (gene p21).
|
20127253 |
2010 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study investigates the role of 3 nonsynonymous SNPs in the DNA repair genes XRCC1 (R399Q), RAD51 (G135C) and TP53 (Arg72Pro) in breast cancer in Serbian women.
|
26954070 |
2016 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the risk of breast cancer: a case control study from South India.
|
17696741 |
2008 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two out of the four p53(wt) relapsing breast cancer patients showed the Arg72Pro allelic variant; one of these died at 75 months.
|
12702523 |
2003 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These observations suggested that neither the Ins16bp or Arg72Pro polymorphisms considered separately, nor any related haplotype, were associated with breast cancer risk in BRCA-mutation negative familial cases.
|
18640791 |
2008 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the rs1042522 polymorphism of TP53 was significantly higher in all groups of patients with breast cancer compared with the control group.
|
27644661 |
2016 |