|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The other two SNPs (rs2046210 and rs3734805) were strongly associated with susceptibility to breast cancer.
|
27525837 |
2016 |
|
rs2046210
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages.
|
19219042 |
2009 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.
|
23888322 |
2013 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A recent genome-wide association study identified a novel single nucleotide polymorphism (SNP), rs2046210, in the 6q25 region as a breast cancer susceptibility locus in Chinese and subsequently replicated in a multicenter study.
|
21528353 |
2011 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs2046210 at 6q25.1, located upstream of the gene encoding estrogen receptor alpha (ESR1), showed strong and consistent association with breast cancer across all three stages.
|
19219042 |
2009 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily so in other ancestral populations, and genotyped them in breast cancer case:control samples of Asian, European, and African origin, a total of 10,176 cases and 13,286 controls.
|
20661439 |
2010 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results suggested that the rs2046210 was associated with breast cancer in a Northern Chinese population, and some SNPs were also associated with breast cancer characteristics.
|
21197568 |
2011 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In joint analyses that included both SNPs, the rs2046210-A allele was associated with increased risk of breast cancer [odds ratio (OR) = 1.14; 95% confidence interval (CI) = 1.02-1.28], and the rs2046211-G allele was associated with reduced risk (OR = 0.80; 95% CI = 0.67-0.95).
|
23104177 |
2013 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Despite some limitations, this meta-analysis demonstrates that the rs2046210 polymorphism may be a risk factor associated with increased breast cancer risk.
|
23609471 |
2013 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results indicated that both polymorphisms were significantly associated with the risk of breast cancer, with per allele OR = 1.35, (95%CI = 1.17-1.57) for rs2046210 and per allele OR = 1.24 (95%CI = 1.06-1.45) for rs4784227.
|
25531440 |
2014 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, our findings suggested that the rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians.
|
30693664 |
2019 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results provide strong evidence to support that the common polymorphism near the ESR1 gene, rs2046210, is associated with an increased risk of breast cancer in Asian and European populations but not in Africans, although the biological mechanisms need to be further investigated.
|
23272245 |
2012 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, all of the five SNPs contributed to breast cancer susceptibility in a dominant genetic model (2q35, rs13387042: adjusted OR = 1.26, P = 0.006; 3q24.1, rs2307032: adjusted OR = 1.24, P = 0.005; 6q22.33, rs2180341: adjusted OR = 1.22, P = 0.006; 6q25.1, rs2046210: adjusted OR = 1.51, P = 2.40 × 10-8; 10q26.13, rs2981582: adjusted OR = 1.31, P = 1.96 × 10-4).
|
22269215 |
2012 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, C6ORF97 showed significant worse prognostic values especially in luminal B subtype in the publically available data sets. rs2046210 and the upstream gene C6ORF97 might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients, which suggests that functional studies of this locus are imperative.
|
25370037 |
2015 |
|
rs2046210
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After adjusting for rs2046210, the association of rs6913578 with breast cancer risk in African Americans approached borderline significance.
|
21303983 |
2011 |
|
rs2046210
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A dose-dependent association was observed between the risk of breast cancer and the genetic risk score, which was an aggregate measure of alleles in seven selected variants, namely FGFR2-rs2981579, TOX3/TNRC9-rs3803662, C6orf97-rs2046210, 8q24-rs13281615, SLC4A7-rs4973768, LSP1-rs38137198, and CASP8-rs10931936.
|
22160591 |
2012 |
|
rs889312
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Relevant data indicate that SNP rs889312 in MAP3K1 is correlated with BC susceptibility only in BRCA2 mutation carriers, but is not associated with an increased risk in BRCA1 carriers.
|
21996731 |
2012 |
|
rs889312
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry.
|
25529635 |
2015 |
|
rs889312
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies novel breast cancer susceptibility loci.
|
17529967 |
2007 |
|
rs889312
|
|
|
0.800 |
GeneticVariation |
BEFREE |
When the FGFR2 ht2 and MAP3K1 rs889312 were evaluated as risk alleles, the risk of BC increased in a dose-dependent manner as the number of risk alleles increased (P trend <0.0001), indicating an additive effect.
|
23225170 |
2013 |
|
rs889312
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that rs889312-C allele and rs16886165-G allele might be risk factors for breast cancer, especially in Europeans and Asians.
|
24595411 |
2014 |
|
rs889312
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We focus on TNRC9 rs3803662, FGFR2 rs1219648 and rs2981582, MAP3K1 rs889312, and 2q35 rs13387042, to replicate in the 4-Corner's Breast Cancer Study of Hispanic (N = 565 cases and 714 controls) and non-Hispanic white (NHW) women (N = 1177 cases and 1330 controls).
|
21475998 |
2011 |