|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
P21 Ser31Arg and FGFR2 rs2981582 Polymorphisms as Risk Factors for Early Onset of Breast Cancer in Yogyakarta, Indonesia.
|
31759353 |
2019 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The SNPs of FGFR2 rs1219648 and PI3KCA rs6443624 may contribute to the identification of breast cancer patients at risk of more aggressive disease and may be potential prognostic factors in breast cancer in a Chinese population.
|
29872343 |
2018 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The association of the fibroblast growth factor receptor 2 gene (<i>FGFR2</i>) polymorphism rs2981582 with breast cancer has been extensively studied, whereas the role of this polymorphism in non-functioning pituitary adenoma (NFPA) has not been elucidated.
|
30206133 |
2018 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis of case-control studies provides strong evidence that fibroblast growth factor 2 (FGFR2; rs11200014, rs2981579, and rs1219648) polymorphisms are significantly associated with the BC risk.
|
29390357 |
2017 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to analyse the discriminative ability of each SNP and to test the accuracy of the predictive breast cancer risk model which includes all SNPs.
|
29372690 |
2017 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis of case-control studies provides strong evidence that FGFR2 (rs2981582, rs2420946 and rs2981578) polymorphisms were significantly associated with the BC risk.
|
27966449 |
2017 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women.
|
27572905 |
2016 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women.
|
27572905 |
2016 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings indicate that the GG genotype of rs12443621 is associated with increased breast cancer risk whereas the GA and AA genotypes of rs2981582 are reduced risk in Han Chinese population.
|
26911390 |
2016 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03-1.39), 1.24 (1.07-1.43), and 1.17 (1.01-1.36), respectively.
|
26421298 |
2015 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicated a statistically significant association (p<0.05) between rs1219648, but not rs1042522, and risk of breast cancer.
|
25292094 |
2014 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In a group of 31 cases diagnosed with breast cancer and 30 healthy women with matched ages, the single-nucleotide polymorphisms (SNPs) rs1219648, rs2981582 in FGFR2 gene were identified by sequence analysis and the SNPs rs10754339, rs10801935, and rs3738414 in the B7-H4 gene were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
|
24125968 |
2014 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Exercise activity and FGFR2 rs2981582 were confirmed to be associated with breast cancer risk, and were found to significantly interact (P for multiplicative and additive interactions = 0.045 and 0.021, respectively).
|
25270516 |
2014 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was stronger evidence of an interaction between ever use of estrogen-only HT and increasing number of rs1219648 risk alleles to increase breast cancer risk (interaction P = 0.08).
|
23435034 |
2013 |
|
rs1219648
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the haplotype analysis, the FGFR2 rs2981582 T / rs2420946 T / rs1219648 G haplotype (ht2) was associated with a significantly increased BC risk compared with the rs2981582 C / rs2420946 C / rs1219648 A haplotype in familial BC and in non-familial early-onset BC (OR = 1.32, 95 % CI 1.06-1.65, P = 0.012; OR = 1.46, 95 % CI 1.11-1.91, P = 0.004, respectively).
|
23225170 |
2013 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To investigate this inconsistency, we performed a meta-analysis of 37 studies involving a total of 288,142 subjects for rs2981582, rs1219648, and rs2420946 polymorphism of the FGFR2 gene to evaluate the effect of FGFR2 on genetic susceptibility for BC.
|
23184080 |
2013 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We investigated the associations between breast cancer risk and the polymorphisms of FGFR2 rs2981582, FGF1 rs250108, and RBFOX2 rs2051579 among 839 incident breast cancer cases and 863 age-matched controls in the Guangzhou Breast Cancer Study.
|
23143756 |
2013 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This is the first study exploring the association between rs2981582 polymorphism in the FGFR2 gene and breast cancer risk in Mexican women.
|
24054997 |
2013 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We observed few significant associations with breast cancer risk overall or by menopausal status other than for FGFR2 rs2981582.
|
23912956 |
2013 |
|
rs2981582
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |