|
rs6220
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P = .031).
|
30572549 |
2018 |
|
rs6220
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs6220
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs7136446
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs7136446
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs1520220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis stratified by cancer type suggested that rs1520220 was not associated with susceptibility to breast cancer.
|
30111277 |
2018 |
|
rs6214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, in stratified analyses, we found that rs6214 was associated with a significantly reduced risk of breast cancer under the allele, heterozygote, and dominant models (A vs G: OR, 0.94, 95% CI,0.88-1.00, P = .044; GA vs GG: OR, 0.88, 95% CI, 0.80-0.97, P = .012; AA + GA vs GG: OR, 0.89, 95% CI, 0.81-0.97, P = .011), as well as pancreatic cancer under the recessive model (AA vs GA + GG: OR, 0.68, 95% CI,0.53-0.87, P = .003).
|
30572549 |
2018 |
|
rs1239905891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |