rs397507444
|
|
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0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies.
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15921520 |
2005 |
rs397507444
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0.100 |
GeneticVariation |
BEFREE |
C667T, and to a lesser extent A1298C polymorphisms, are also reported to influence the cytotoxic effect of fluoropyrimidines and antifolates providing support for their pharmacogenetic role in predicting the efficacy and the toxicity in cancer and rheumatoid arthritis patients.
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18781847 |
2008 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C-->T and 1298 A-->C have shown to impact several diseases including cancer.
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20516537 |
2010 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer.
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21732284 |
2011 |
rs397507444
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|
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0.100 |
GeneticVariation |
BEFREE |
We evaluated the C677T and A1298C polymorphisms using the TaqMan allelic discrimination assay in various malignancies.
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17156840 |
2007 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) play an essential role in both DNA synthesis and methylation and polymorphisms in the MTHFR gene, 677C>T, 1298A>C and the MTRR gene, 66A>G, are associated with several types of malignancy.
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19035314 |
2008 |
rs397507444
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0.100 |
GeneticVariation |
BEFREE |
Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.
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22901194 |
2012 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies.
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25510667 |
2015 |
rs397507444
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0.100 |
GeneticVariation |
BEFREE |
However, the mutant C allele of MTHFR A1298C was significantly higher in the cancer group than in the normal group.
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29740106 |
2018 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
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16777985 |
2006 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
A retrospective comparative exploratory study on two methylentetrahydrofolate reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients.
|
24490800 |
2014 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
Two common genetic variants, C677T and A1298C, of MTHFR are associated with number of human diseases, including cancer, as well as being involved in the modulation of therapy outcome to antifolate drugs.
|
24533714 |
2014 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
Accumulating evidence has indicated that two common genetic variants, C677T and A1298C, are associated with cancer risk.
|
20002681 |
2010 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer.
|
22194208 |
2011 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate as a cancer-predisposing factor.
|
17712558 |
2007 |
rs397507444
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0.100 |
GeneticVariation |
BEFREE |
Multiplex PCR for simultaneous detection of 677 C-->T and 1298 A-->C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk.
|
12175537 |
2002 |
rs397507444
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|
|
0.100 |
GeneticVariation |
BEFREE |
Two common polymorphisms are reported, C677T and A1298C, that are implicated in a number of human diseases, including cancer.
|
25921104 |
2015 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development.
|
26745044 |
2015 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
|
23076526 |
2013 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
Interactions were observed between the MTHFR A1298C polymorphism and bowel habits, family history of cancer, alcohol consumption, and beef consumption on colon cancer risk (P-value for interaction = 0.0005, 0.007, 0.067, 0.003, respectively).
|
20551579 |
2010 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
This study aims to evaluate the role of MTHFR C677T and A1298C polymorphisms and G80A reduced folate carrier gene (RFC1) in a cohort of adult patients with lymphoproliferative malignancies submitted to high-dose MTX followed by leucovorin rescue.
|
21984221 |
2012 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
Overall, significant association was observed between MTHFR A1298C polymorphism and cancer risk when all eligible studies were pooled into the meta-analysis.
|
26156333 |
2016 |
rs397507444
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|
0.100 |
GeneticVariation |
BEFREE |
In this meta-analysis, we include 14 studies that focus on MTHFR C677T and A1298C polymorphisms in pediatric patients with malignancy.
|
28696419 |
2018 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common methylenetetrahydrofolate reductase gene variants (MTHFR C677T and A1298C) have been described to have opposite effects on cancer patients.
|
17488658 |
2007 |