| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | BEFREE | Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy. | 25605158 | 2014 |
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|
0.070 | GeneticVariation | BEFREE | ATM rs1801516 polymorphism is not associated with overall cancer risk in total population. | 30384829 | 2018 |
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|
0.070 | GeneticVariation | BEFREE | The IVS24-9 T/(-T), IVS38-8 T/C, 5557 G/A composite genotype alone or in combination with certain genetic background and/or environmental factors, could modify the cancer risk by increasing genetic instability or by altering the effect of the normal DNA damage response. | 18433505 | 2008 |
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|
0.070 | GeneticVariation | BEFREE | Neither of the two common variants, 5557G>A and ivs38-8T>C, nor any haplotype containing them, was significantly associated with breast cancer risk, bilateral breast cancer or multiple primary cancers in any of the patient groups or subgoups. | 16914028 | 2006 |
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|
0.070 | GeneticVariation | BEFREE | Single Nucleotide Polymorphism rs1801516 in Ataxia Telangiectasia-Mutated Gene Predicts Late Fibrosis in Cancer Patients After Radiotherapy: A PRISMA-Compliant Systematic Review and Meta-Analysis. | 27057881 | 2016 |
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|
0.070 | GeneticVariation | BEFREE | Based on the results, we propose a cancer risk-modifying effect for the ATM 5557G-->A, IVS38-8T-->C composite allele. | 15756685 | 2005 |
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|
0.070 | GeneticVariation | BEFREE | Our meta-analyses confirmed the presence of a gene-environment interaction between the rs1801516 polymorphism and radiation exposure in carcinogenesis, whereas no association was found between the rs1801516 polymorphism and cancer risk for individuals without radiation exposure. | 27764772 | 2016 |