Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs149065728
rs149065728
0.010 GeneticVariation BEFREE Design and synthesis of diphenylpyrimidine derivatives (DPPYs) as potential dual EGFR T790M and FAK inhibitors against a diverse range of cancer cell lines. 31706682

2020

dbSNP: rs1799963
rs1799963
F2
0.010 GeneticVariation BEFREE We compared the incidence of cancer diagnosis during follow-up among cohort women positive for antiphospholipid antibodies (n=517), cohort women carrying the F5 rs6025 or F2 rs1799963 polymorphism (n=279) and cohort women with negative thrombophilia screening results (n=796). 31101755

2020

dbSNP: rs2071214
rs2071214
0.010 GeneticVariation BEFREE An upgrade risk in rs9904341 of BIRC5 were revealed to be associated with urinary cancer in allele contrast model (OR = 1.222, P = 0.012), homozygote contrast model (OR = 1.579, P = 0.0001) and recessive contrast model (OR = 1.433, P < 0.001), as well as rs2071214 polymorphism in the subgroup analysis of BCa in allele contrast model (OR = 1.362, P = 0.011) and recessive contrast model (OR = 1.417, P = 0.015). 31809840

2020

dbSNP: rs2470151
rs2470151
0.010 GeneticVariation BEFREE Stratified analyses showed the association between rs2470151 and the risk of colorectal cancer were influenced by family history of cancer, smoking, alcohol consumption, and tea drinking. 31789575

2020

dbSNP: rs2569190
rs2569190
0.010 GeneticVariation BEFREE Two polymorphisms, -260 C>T (rs2569190) and -561 C>T (rs5744455), in the CD14 gene have been implicated in susceptibility to cancer. 31826310

2020

dbSNP: rs5744455
rs5744455
0.010 GeneticVariation BEFREE Two polymorphisms, -260 C>T (rs2569190) and -561 C>T (rs5744455), in the CD14 gene have been implicated in susceptibility to cancer. 31826310

2020

dbSNP: rs6022999
rs6022999
0.010 GeneticVariation BEFREE Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer </span>susceptibility in Caucasian population and in Asian population respectly. 31740231

2020

dbSNP: rs6068816
rs6068816
0.010 GeneticVariation BEFREE Previous studies proposed that rs2585428, rs4809960, rs6022999 and rs6068816 in CYP24A1 gene might be greatly associated with cancer risk. 31740231

2020

dbSNP: rs63751147
rs63751147
0.010 GeneticVariation BEFREE The MSH2 c.1022T>C variant is a pathogenic founder variation associated with a high risk of cancer. 31433521

2020

dbSNP: rs751144688
rs751144688
0.010 GeneticVariation BEFREE Three of them CD44, S100A7, and S100P were significantly altered in patients with LP as well as OSCC and can be regarded as a panel of biomarker candidates for early detection of the malignancy. 31706945

2020

dbSNP: rs8193
rs8193
0.010 GeneticVariation BEFREE rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population. 31376327

2020

dbSNP: rs10132552
rs10132552
0.010 GeneticVariation BEFREE Certain polymorphisms within MEG3 are implicated in cancer risk (rs7158663, rs4081134 and rs11160608) or therapeutic response of cancer patients (rs10132552). 31326791

2019

dbSNP: rs1049334
rs1049334
0.010 GeneticVariation BEFREE Conclusion rs1049334 polymorphismof CAV1 upgrade the risk of urinary cancer, while rs1049337 and rs7804372 polymorphisms may act as a protector of urinary cancer. 30463805

2019

dbSNP: rs1057519695
rs1057519695
0.010 GeneticVariation BEFREE The activating NRAS p.Q61R variant is a known "hotspot" variant, frequently identified in several types of human cancer, especially melanoma. 30542204

2019

dbSNP: rs1057519736
rs1057519736
0.010 GeneticVariation BEFREE Interestingly, monoclonal antibody 11C8B1 was reactive with all IDH2 R172S (N = 15) mutated tumors including 12 sinonasal carcinomas, 2 high-grade sarcomas and one intrahepatic cholangiocarcinoma, and with all R172T (N = 3) mutated sinonasal carcinomas displaying a distinct granular cytoplasmic labeling in all R172S/T mutated malignancies. 30206411

2019

dbSNP: rs1057519784
rs1057519784
ALK
0.010 GeneticVariation BEFREE Digital PCR analyses combined with microdissection after IHC staining for EMT markers revealed that <i>ALK</i> L1196M was predominantly detected in epithelial-type tumor cells, indicating that mesenchymal phenotype and <i>ALK</i> mutation can coexist as independent mechanisms underlying ALK inhibitor-resistant cancers. 30737231

2019

dbSNP: rs1057519834
rs1057519834
0.010 GeneticVariation BEFREE The activating NRAS p.Q61R variant is a known "hotspot" variant, frequently identified in several types of human cancer, especially melanoma. 30542204

2019

dbSNP: rs1057519895
rs1057519895
0.010 GeneticVariation BEFREE Cancer-associated arginine mutations in the WD40 domain (R465H, R479Q and R505C) abolish both FBXW7 interaction with PAR and recruitment to DNA damage sites, causing inhibition of XRCC4 polyubiquitination and NHEJ. 30722038

2019

dbSNP: rs1057519911
rs1057519911
0.010 GeneticVariation BEFREE The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). 31296562

2019

dbSNP: rs1057519989
rs1057519989
0.010 GeneticVariation BEFREE Direct sequencing revealed that the cancer cells contained a missense mutation (c.730G>A) in the TP53 gene. 30636633

2019

dbSNP: rs1057520001
rs1057520001
0.010 GeneticVariation BEFREE Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk. 31759353

2019

dbSNP: rs1059536
rs1059536
0.010 GeneticVariation BEFREE This work demonstrates that common shared mutated epitopes such as those found in p53 can elicit immunogenic responses and that the application of ACT may be extended to patients with any cancer histology that expresses both HLA-A*0201 and the p53 p.R175H mutation. 30709841

2019

dbSNP: rs1063320
rs1063320
0.010 GeneticVariation BEFREE Several published studies have investigated the relationship between the HLA-G +3142 C>G (rs1063320) polymorphism and cancer susceptibility in different populations. 31232944

2019

dbSNP: rs10680577
rs10680577
0.010 GeneticVariation BEFREE The present result suggests that EGLN2 rs10680577 polymorphism is associated with cancer risk, and may act as a promising predictive biomarker for cancer risk, especially in Chinese population. 31414584

2019

dbSNP: rs11160608
rs11160608
0.010 GeneticVariation BEFREE Certain polymorphisms within MEG3 are implicated in cancer risk (rs7158663, rs4081134 and rs11160608) or therapeutic response of cancer patients (rs10132552). 31326791

2019