Our findings suggest that the HIF-1α A588T polymorphism is significantly associated with higher cancer risk and the P582S polymorphism is significantly associated with pancreatic cancer risk.
In conclusion, our findings suggest that HIF1A Pro582Ser</span> polymorphism may contribute to the risk of digestive tract cancers, especially in Asian populations.
This meta-analysis aims to derive a precise estimation of the association between a common polymorphism (C1772T; rs11549465 C>T) in the HIF-1α gene and susceptibility to GIT cancer.