Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.070 | GeneticVariation | BEFREE | Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis. | 30784231 | 2019 |
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0.070 | GeneticVariation | BEFREE | In addition, the rs2274223 polymorphism was found to be associated with increased cancer</span> risk, especially among the subgroups comprising Asians, studies with population-based controls, studies employing the TaqMan genotyping method, and studies consistent with Hardy-Weinberg equilibrium (HWE). | 30619753 | 2018 |
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0.070 | GeneticVariation | BEFREE | Also those with a hereditary background including the risk alleles PLCE1 rs2274223 and PTGER4/PRKAA1 rs13361707 were 3 times more susceptible to cardia cancer than those without. | 27127881 | 2016 |
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0.070 | GeneticVariation | BEFREE | This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC. | 25614244 | 2015 |
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0.070 | GeneticVariation | BEFREE | A comprehensive search was conducted to identify all eligible studies of PLCE1 rs2274223 polymorphism and digestive tract cancer risk. | 24116107 | 2013 |
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0.070 | GeneticVariation | BEFREE | Our meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer. | 24595086 | 2013 |
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0.070 | GeneticVariation | BEFREE | We found that PLCE1 rs2274223 A>G polymorphism was significantly associated with increased risk of cancer in log additive/dominant model and at allele level (GG vs. AA: OR = 1.24, 95 % CI = 1.01–1.53, P = 0.039; AG vs. AA: OR = 1.24, 95 % CI = 1.16–1.32, P < 0.001; AG + GG vs. AA: OR = 1.22, 95 % CI = 1.12–1.34, P < 0.001; and G vs. A allele: OR = 1.15, 95 % CI = 1.05–1.25, P = 0.002). | 23797815 | 2013 |