These results indicated that genotype.GT/GG of rs61764370 was not a genetic susceptible risk factor for cancer, and rs61764370could not be used as a biomarker for estimating cancer risk in Caucasian population.
These results suggest that the cancer-associated rs61764370 variant exerts a biological effect not through transcriptional modulation of KRAS but rather by tuning the expression of the microRNA let-7.
We previously identified a functional variant in a let-7 microRNA (miRNA) complementary site in the 3'-untranslated region of the KRAS oncogene (rs61764370) which is associated with cancer.