|
rs2234693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that <i>ESR1</i> PvuII (rs2234693 T>C) polymorphism may only have little impact on cancer susceptibility.
|
30123365 |
2018 |
|
rs1801132
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results indicated that ESR1 rs1801132 (C>G) was associated with cancer risk in Caucasian populations.
|
25200861 |
2015 |
|
rs2077647
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, rs2077647 (A>G) was only associated with an increased risk of hepatocellular carcinoma, but was an adverse effect on cancer risk in Caucasian populations.
|
25200861 |
2015 |
|
rs1801132
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor G allele of rs1801132 was protective in our cases (p = 1 × 10(-4)); for rs2228480, the heterozygous frequency was higher for cancer groups (p = 0.03); the SNP pairs rs2228480&rs3798577 and rs2234693&rs9340799 were in low LD; the haplotypes T-A of rs2234693&rs9340799 and G-C of rs2228480&rs3798577 showed a trend to be higher represented in breast cancers; T allele of rs2234693 was higher expressed in breast, colon cancers and leukemia; rs2077647 was associated with colon (p = 0.008, C-risk allele) and bladder (p = 0.01, T-risk allele) cancers.
|
20383761 |
2010 |
|
rs2077647
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor G allele of rs1801132 was protective in our cases (p = 1 × 10(-4)); for rs2228480, the heterozygous frequency was higher for cancer groups (p = 0.03); the SNP pairs rs2228480&rs3798577 and rs2234693&rs9340799 were in low LD; the haplotypes T-A of rs2234693&rs9340799 and G-C of rs2228480&rs3798577 showed a trend to be higher represented in breast cancers; T allele of rs2234693 was higher expressed in breast, colon cancers and leukemia; rs2077647 was associated with colon (p = 0.008, C-risk allele) and bladder (p = 0.01, T-risk allele) cancers.
|
20383761 |
2010 |
|
rs2234693
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor G allele of rs1801132 was protective in our cases (p = 1 × 10(-4)); for rs2228480, the heterozygous frequency was higher for cancer groups (p = 0.03); the SNP pairs rs2228480&rs3798577 and rs2234693&rs9340799 were in low LD; the haplotypes T-A of rs2234693&rs9340799 and G-C of rs2228480&rs3798577 showed a trend to be higher represented in breast cancers; T allele of rs2234693 was higher expressed in breast, colon cancers and leukemia; rs2077647 was associated with colon (p = 0.008, C-risk allele) and bladder (p = 0.01, T-risk allele) cancers.
|
20383761 |
2010 |
|
rs796065354
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here we show that ER-alpha proteins with single or double lysine mutations of these motifs (including K303R, a cancer-associated mutant) are resistant to inhibition by BRCA1, even though the mutant ER-alpha proteins retain the ability to bind to BRCA1.
|
19887647 |
2010 |
|
rs796065354
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The fact that the mutation was not found leads us to believe that this mutation is absent from most cells in invasive carcinomas and furthermore that the major expression product of the ER-alpha gene in cancers does not contain the K303R mutation.
|
15642159 |
2005 |
|
rs200075329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, there was no difference in the prevalence of S118P between women with and without cancer relative to population registry databases.
|
30560461 |
2019 |
|
rs762292600
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conclusion This study provides the first clinical data that AKT1 E17K is a therapeutic target in human cancer.
|
28489509 |
2017 |
|
rs2228480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor G allele of rs1801132 was protective in our cases (p = 1 × 10(-4)); for rs2228480, the heterozygous frequency was higher for cancer groups (p = 0.03); the SNP pairs rs2228480&rs3798577 and rs2234693&rs9340799 were in low LD; the haplotypes T-A of rs2234693&rs9340799 and G-C of rs2228480&rs3798577 showed a trend to be higher represented in breast cancers; T allele of rs2234693 was higher expressed in breast, colon cancers and leukemia; rs2077647 was associated with colon (p = 0.008, C-risk allele) and bladder (p = 0.01, T-risk allele) cancers.
|
20383761 |
2010 |
|
rs772596249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the five tagSNPs in this region was in strong linkage disequilibrium (LD) with the untranslated A61G (rs4444903) EGF variant, earlier shown to be associated with risk for other forms of cancer.
|
19319135 |
2009 |
|
rs149308960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three patients with a family history of cancer were carrying a Gly160Cys germline substitution.
|
9195227 |
1997 |