Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). 23977225

2013

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE The results suggested that the MDR1 C3435T polymorphism may contribute to cancer risk. 22311042

2012

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE We therefore investigated the influence of polymorphisms G1199A, C1236T, G2677T/A and C3435T on cancer susceptibility, in vitro cytotoxicity and overall survival in 100 de novo AML patients with normal karyotype. 20938465

2012

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE The C3435T polymorphism of the MDR1 gene may influence the transport and excretion of carcinogens, increasing the risk of cancer. 22641402

2012

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is associated with cancer susceptibility, increasing the risk of breast and renal cancer. 22358302

2012

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Polymorphism ABCB1 (3435C>T) may be a prediction marker of cancer chemotherapy effectiveness. 19415305

2009

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE Recently, association between the MDR1 C3435T polymorphism and the cancer susceptibility was shown. 17300681

2007

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, however, has not yet been clearly defined. 17146660

2007

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE We investigated the incidence of C3435T polymorphisms at exon 26 in the MDR-1 gene in 92 women with breast cancer and potential association of altered genotypes with smoking and high body mass index in cancer development among patients. 17549370

2007

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE This study investigates the association between ABCB1 gene polymorphism at exon 26 (3435C>T) and risk to UADT cancers in Tamilians, a population of south India. 17885624

2007

dbSNP: rs1045642
rs1045642
0.100 GeneticVariation BEFREE These results suggest that ABCB1 3435C>T polymorphism is associated with antiemetic treatment efficacy in patients with cancer treated with 5-HT(3) antagonists, particularly in granisetron-treated patients, during the short-term phase of chemotherapy. 16338277

2005

dbSNP: rs3789243
rs3789243
0.020 GeneticVariation BEFREE We have previously found association between the ABCB1 C-rs3789243-T polymorphism and CRC risk and interactions between the ABCB1 C-rs3789243-T and C3435T polymorphisms and meat intake in relation to CRC risk (Andersen, BMC Cancer, 2009, 9, 407). 23977225

2013

dbSNP: rs3789243
rs3789243
0.020 GeneticVariation BEFREE No association was found between the MDR1 polymorphism (G-rs3789243-A) and colorectal adenomas or cancer. 19250544

2009

dbSNP: rs3842
rs3842
0.010 GeneticVariation BEFREE In addition, stratification analysis demonstrated a remarkable association of ABCB1 rs3842 with the risk of cancer manifested in women (OR, 2.57; 95% CI, 1.36-4.85), in the histologic type of adenocarcinoma (OR, 1.42; 95% CI, 1.03-1.99), and in individuals aged <60 years (OR, 1.50; 95% CI, 1.05-2.14). 19107762

2009

dbSNP: rs2229109
rs2229109
0.010 GeneticVariation BEFREE We and others have reported a number of functionally significant MDR1 variants, including G1199A and G1199T, that modulate cancer drug resistance and intracellular levels of antivirals. 18723777

2008

dbSNP: rs2032582
rs2032582
0.010 GeneticVariation BEFREE The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, however, has not yet been clearly defined. 17146660

2007