| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.030 | GeneticVariation | BEFREE | The obtained results allow us to conclude: (i) survival times of 500 C/G carriers vs. cumulating proportion surviving was not statistically significant; (ii) CDKN2a polymorphism 500 C/G correlated with Ala148Thr; (iii) no correlation was observed between the 500 C/G polymorphism and age of diagnosis, localization of primary melanoma and survival time; (iv) we did not find correlation between 500 C/G and type of cancer in the family; (v) changes in the CDKN2a gene were not found in patients with second cancer. | 17351674 | 2007 |
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0.030 | GeneticVariation | BEFREE | These results suggest that A148T variant may be associated with a multi-organ cancer risk in the Polish population. | 16395703 | 2006 |
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0.030 | GeneticVariation | BEFREE | The A148T carrier population (heterozygous G/A alleles) was more likely to have a relative with malignancy compared with the noncarrier population (57% versus 36%, respectively; P = 0.03). | 15705881 | 2005 |
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0.010 | GeneticVariation | BEFREE | In addition, CDKN2A rs11515 polymorphism might associate with cancer risk in Asians. | 28466822 | 2017 |
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0.010 | GeneticVariation | BEFREE | Dysfunction of individual annexin and S100A proteins is associated with cancer progression, metastasis and cancer drug resistance. | 28068434 | 2017 |
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0.010 | GeneticVariation | BEFREE | Overall, we found that rs3731249, rs11515, and rs3088440 polymorphisms were not associated with cancer risk (OR=1.27, 95%CI: 0.79-2.03; OR=0.91, 95%CI: 0.79-1.03; OR=1.02, 95%CI: 0.95-1.09). | 28466822 | 2017 |
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|
0.010 | GeneticVariation | BEFREE | In conclusion, our results illustrate that the K-Ras(V14I) activating protein is able to induce cancer, although at a much lower level than the classical K-Ras(G12V) oncogene, and that it can be significantly modulated by both genetic and non-genetic events. | 27174785 | 2016 |
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0.010 | GeneticVariation | BEFREE | The importance of the CDK4 locus in human cancer first became evident following the identification of a germ line CDK4-Arg24Cys (R24C) mutation, which abolishes the ability of CDK4 to bind to p16(INK4a). | 11756559 | 2002 |