|
rs1136201
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) of P53 Pro72Arg, MDM2 SNP309, P21 Ser31Arg, ER SNP594, HER2 Ile655Val, and FGFR2 rs2981582 have drawn attention as genetic factors associated with cancer risk.
|
31759353 |
2019 |
|
rs1136201
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, the current study reveals a significant association between cancer susceptibility and the HER-2 Ile655Val polymorphism in all genetic models.
|
27293060 |
2016 |
|
rs1136201
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, we did not find a significant association between the distribution of genotypes or alleles and cancer characteristics for the HER2 Ile655Val polymorphism.
|
20026098 |
2010 |
|
rs977818812
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The majority (93%) of <i>HER2</i> mutations were hotspot V659E transmembrane domain (TMD) mutations comparable to activating mutations at this same site in human cancer.
|
31431454 |
2019 |
|
rs372811772
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutations were C250T in the triple-negative cancer case and C228T in the remaining two cases.
|
29222734 |
2018 |
|
rs752295912
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL7RA Thr244Ile was genotyped through PCR-RFLP in 403 women without neoplasia, no personal history of malignancy or family history of BC and in 338 BC patients with clinicopathological data available.
|
28964592 |
2018 |
|
rs749539903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One EBV-positive cancer with PIK3CA mutation (H1047R) was MSI-positive.
|
23236232 |
2012 |
|
rs368094521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, using G129R-based fusion proteins to target mammary carcinomas and to tackle multiple hallmarks of cancer at the same time was an effective strategy for treating HER2-postive mammary cancer in this mouse tumor model.
|
19287973 |
2009 |
|
rs372043866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, we observed that the combination of PI3K-mTOR and MEK inhibitors effectively shrunk tumors in a transgenic and xenograft model of EGFR T790M-L858R cancers.
|
19850869 |
2009 |
|
rs121913470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ErbB2 mutants associated with lapatinib resistance transformed NIH-3T3 cells, including L755S and T733I mutations known to occur in human breast and gastric carcinomas, supporting a direct mechanism for lapatinib resistance in ErbB2-driven human cancers.
|
18413839 |
2008 |