Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs16906252
rs16906252
0.010 GeneticVariation BEFREE Other SNPs associated with the risk of colon cancer (e.g., rs16906252 in MGMT) were found to affect mRNA expression levels in colon transverse and therefore working as possible cis-eQTL suggesting possible mechanisms of carcinogenesis. 31209889

2020

dbSNP: rs2189517
rs2189517
0.010 GeneticVariation BEFREE Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10<sup>-6</sup> ) and rs2189517 (in RAD51B) with rectal cancer risk (p-value = 5.7 × 10<sup>-6</sup> ). 31209889

2020

dbSNP: rs2585428
rs2585428
0.010 GeneticVariation BEFREE Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly. 31740231

2020

dbSNP: rs4809960
rs4809960
0.010 GeneticVariation BEFREE Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly. 31740231

2020

dbSNP: rs6022999
rs6022999
0.010 GeneticVariation BEFREE Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly. 31740231

2020

dbSNP: rs6068816
rs6068816
0.010 GeneticVariation BEFREE Moreover, the analysis of haplotypes consisting of rs2585428(G > A), rs4809960(T > C), rs6022999(A > G) and rs6068816(C > T) indicated that haplotype ATGC significantly decreased the CRC risk, especially the colon cancer risk. 31740231

2020

dbSNP: rs1057519725
rs1057519725
0.010 GeneticVariation BEFREE Furthermore, we characterized KRAS A146V biologically using colon cancer cells. 30448735

2019

dbSNP: rs1057519822
rs1057519822
0.010 GeneticVariation BEFREE V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer. 31227518

2019

dbSNP: rs11615
rs11615
0.010 GeneticVariation BEFREE In women, the rs11615 CC genotype worsened TTN (co-dominant model p = 0.008, recessive model p = 0.003) and rs13181 G allele improved the TTG (p = 0.039). 31395900

2019

dbSNP: rs121913227
rs121913227
0.010 GeneticVariation BEFREE The kinetics of ctDNA derived from each cancer type were monitored targeting BRAF V600R (melanoma) and KRAS G13D (colon cancer), specifically reflected the status of the patient's tumours. 31727009

2019

dbSNP: rs13181
rs13181
0.010 GeneticVariation BEFREE In women, the rs11615 CC genotype worsened TTN (co-dominant model p = 0.008, recessive model p = 0.003) and rs13181 G allele improved the TTG (p = 0.039). 31395900

2019

dbSNP: rs1323151304
rs1323151304
0.010 GeneticVariation BEFREE Here, we identified a germline frameshift variation in the POLE gene (c.4191_4192delCT, p.Tyr1398*) in a case with multiple adenomatous polyps and three synchronous colon cancers. 31089268

2019

dbSNP: rs13281615
rs13281615
0.010 GeneticVariation BEFREE PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis. 30820968

2019

dbSNP: rs187960998
rs187960998
0.010 GeneticVariation BEFREE rs187960998 in miR-211 was highly associated with a decreased risk of CC in the Chinese population by deregulating a tumor suppressive gene CHD5. 30655677

2019

dbSNP: rs1902432
rs1902432
0.010 GeneticVariation BEFREE And the rs1902432 SNP might only have potential to be a biomarker for colon cancer risk. 31253700

2019

dbSNP: rs2910164
rs2910164
0.010 GeneticVariation BEFREE PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis. 30820968

2019

dbSNP: rs3748067
rs3748067
0.010 GeneticVariation BEFREE Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC. 31138901

2019

dbSNP: rs3804513
rs3804513
0.010 GeneticVariation BEFREE Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC. 31138901

2019

dbSNP: rs4135113
rs4135113
TDG
0.010 GeneticVariation BEFREE The AA genotype of the <i>TDG</i> SNP rs4135113 increased the risk of colon cancer development by more than 3.6-fold, whereas the minor allele A increased the risk by 1.6-fold. 31239841

2019

dbSNP: rs41395947
rs41395947
0.010 GeneticVariation BEFREE In contrast, for variant G128C, there was no significant association with the risk of developing colon cancer. 30834416

2019

dbSNP: rs41494447
rs41494447
0.010 GeneticVariation BEFREE Novel association between heterozygous genotype of single nucleotide polymorphism C218T in drug transporter ABCC1 gene and increased risk of colon cancer. 30834416

2019

dbSNP: rs6854845
rs6854845
0.010 GeneticVariation BEFREE SNP rs6854845 was suggested to be a risk of colon cancer in human population. 31078271

2019

dbSNP: rs7747909
rs7747909
0.010 GeneticVariation BEFREE Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC. 31138901

2019

dbSNP: rs121913273
rs121913273
0.010 GeneticVariation BEFREE However, the cluster drawn by the two mutations of V600E and E542K showed that all samples with those mutations belonged to the right-sided colon cancer group. 29556349

2018

dbSNP: rs121913412
rs121913412
0.010 GeneticVariation BEFREE Colon cancers carrying BRAF V600E and β-catenin T41A activating mutations are resistant to numerous common anticancer drugs. 29541216

2018