rs16906252
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other SNPs associated with the risk of colon cancer (e.g., rs16906252 in MGMT) were found to affect mRNA expression levels in colon transverse and therefore working as possible cis-eQTL suggesting possible mechanisms of carcinogenesis.
|
31209889 |
2020 |
rs2189517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs1800734 (in MLH1 gene) was associated with colon cancer risk (p-value = 3.5 × 10<sup>-6</sup> ) and rs2189517 (in RAD51B) with rectal cancer risk (p-value = 5.7 × 10<sup>-6</sup> ).
|
31209889 |
2020 |
rs2585428
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly.
|
31740231 |
2020 |
rs4809960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly.
|
31740231 |
2020 |
rs6022999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the rs4809960 and rs6022999 may be the genetic biomarkers for prediction of colon cancer risk in Chinese population, the rs2585428 and rs6022999 may link to cancer susceptibility in Caucasian population and in Asian population respectly.
|
31740231 |
2020 |
rs6068816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the analysis of haplotypes consisting of rs2585428(G > A), rs4809960(T > C), rs6022999(A > G) and rs6068816(C > T) indicated that haplotype ATGC significantly decreased the CRC risk, especially the colon cancer risk.
|
31740231 |
2020 |
rs1057519725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we characterized KRAS A146V biologically using colon cancer cells.
|
30448735 |
2019 |
rs1057519822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.
|
31227518 |
2019 |
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In women, the rs11615 CC genotype worsened TTN (co-dominant model p = 0.008, recessive model p = 0.003) and rs13181 G allele improved the TTG (p = 0.039).
|
31395900 |
2019 |
rs121913227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The kinetics of ctDNA derived from each cancer type were monitored targeting BRAF V600R (melanoma) and KRAS G13D (colon cancer), specifically reflected the status of the patient's tumours.
|
31727009 |
2019 |
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In women, the rs11615 CC genotype worsened TTN (co-dominant model p = 0.008, recessive model p = 0.003) and rs13181 G allele improved the TTG (p = 0.039).
|
31395900 |
2019 |
rs1323151304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we identified a germline frameshift variation in the POLE gene (c.4191_4192delCT, p.Tyr1398*) in a case with multiple adenomatous polyps and three synchronous colon cancers.
|
31089268 |
2019 |
rs13281615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis.
|
30820968 |
2019 |
rs187960998
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs187960998 in miR-211 was highly associated with a decreased risk of CC in the Chinese population by deregulating a tumor suppressive gene CHD5.
|
30655677 |
2019 |
rs1902432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And the rs1902432 SNP might only have potential to be a biomarker for colon cancer risk.
|
31253700 |
2019 |
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PVT1 (rs13281615) and miR-146a (rs2910164) polymorphisms affect the prognosis of colon cancer by regulating COX2 expression and cell apoptosis.
|
30820968 |
2019 |
rs3748067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
rs3804513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
rs4135113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype of the <i>TDG</i> SNP rs4135113 increased the risk of colon cancer development by more than 3.6-fold, whereas the minor allele A increased the risk by 1.6-fold.
|
31239841 |
2019 |
rs41395947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, for variant G128C, there was no significant association with the risk of developing colon cancer.
|
30834416 |
2019 |
rs41494447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Novel association between heterozygous genotype of single nucleotide polymorphism C218T in drug transporter ABCC1 gene and increased risk of colon cancer.
|
30834416 |
2019 |
rs6854845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs6854845 was suggested to be a risk of colon cancer in human population.
|
31078271 |
2019 |
rs7747909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strong association of rs3819025, rs3804513, and rs7747909 was found with tolerance to RC treatment. rs3748067 was associated with FOLFOX tolerance in CC but not RC.
|
31138901 |
2019 |
rs121913273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the cluster drawn by the two mutations of V600E and E542K showed that all samples with those mutations belonged to the right-sided colon cancer group.
|
29556349 |
2018 |
rs121913412
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Colon cancers carrying BRAF V600E and β-catenin T41A activating mutations are resistant to numerous common anticancer drugs.
|
29541216 |
2018 |