DisGeNET - a database of gene-disease associations

Malignant neoplasm of larynx, C0007107

Variant: rs25487 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs25487

XRCC1

0.030

GeneticVariation

BEFREE

In this study, we attempted to assess the association between XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphisms and risk of laryngeal cancer in a Chinese population.

27808358

2016

dbSNP:

rs25487

XRCC1

0.030

GeneticVariation

BEFREE

Overall, our results found that only AA genotype of the XRCC1 gene Arg399Gln polymorphism under the homozygous model was associated with increased the risk of patients with laryngeal cancer (AA vs. GG: OR=1.29, 95% CI=1.00-1.65, P=0.05).

26898429

2016

dbSNP:

rs25487

XRCC1

0.030

GeneticVariation

BEFREE

Therefore, we concluded that XRCC1 gene Arg399Gln polymorphism was not associated with laryngeal cancer.

24194393

2014