| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.740 | GeneticVariation | BEFREE | We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib. | 20522446 | 2010 |
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|
0.740 | GeneticVariation | BEFREE | A female patient with advanced NSCLC with a single S768I mutation achieved effectiveness from afatinib after showing no response to gefitinib. | 29731638 | 2018 |
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|
0.740 | GeneticVariation | BEFREE | Consistently, afatinib was clinically effective for the treatment of NSCLC harboring G719C and S768I mutations of EGFR. | 27794398 | 2016 |
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|
0.740 | GeneticVariation | BEFREE | We used a natural language search program to search our electronic medical record system and every EGFR mutation analysis of patients with NSCLC treated at Mayo Clinic that was performed in our Department of Molecular Genetics to identify patients with EGFR S768I mutation. | 27211795 | 2016 |
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|
TT | 0.740 | CausalMutation | CLINVAR | Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. | 19147750 | 2009 |
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|
TT | 0.740 | CausalMutation | CLINVAR | High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan. | 15623594 | 2004 |
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|
TT | 0.740 | CausalMutation | CLINVAR | Lung cancer with epidermal growth factor receptor exon 20 mutations is associated with poor gefitinib treatment response. | 18676761 | 2008 |
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|
TT | 0.740 | CausalMutation | CLINVAR | Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L. | 17045698 | 2006 |
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|
TT | 0.740 | CausalMutation | CLINVAR | Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants. | 16205628 | 2006 |
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|
TT | 0.740 | CausalMutation | CLINVAR | Comparing ICA-based and single-trial topographic ERP analyses. | 20422446 | 2010 |