Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR "Effectiveness of tyrosine kinase inhibitors on ""uncommon"" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer." 21531810

2011

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR "EGF receptor gene mutations are common in lung cancers from ""never smokers"" and are associated with sensitivity of tumors to gefitinib and erlotinib." 15329413

2004

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. 15118073

2004

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. 16115929

2005

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors. 23242437

2013

dbSNP: rs121913428
rs121913428
0.740 GeneticVariation BEFREE Corrigendum: Afatinib for Advanced Non-small Cell Lung Cancer in a Case With an Uncommon Epidermal Growth Factor Receptor Mutation (G719A) Identified in the Cerebrospinal Fluid. 31641649

2019

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Effects of marine oil-enriched diets on guinea pig megakaryocyte and platelet lipids: effects on thromboxane synthesis and platelet function. 2302402

1990

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. 15118125

2004

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer. 19922469

2010

dbSNP: rs121913428
rs121913428
A 0.740 GeneticVariation CLINVAR Erlotinib response in an NSCLC patient with a novel compound G719D+L861R mutation in EGFR. 23945392

2013

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. 18458038

2008

dbSNP: rs121913428
rs121913428
0.740 GeneticVariation BEFREE Low frequency KRAS active (G12R) and EGFR kinase domain mutations (G719A) were identified in one NSCLC patient. 24200637

2014

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 23102728

2013

dbSNP: rs121913428
rs121913428
0.740 GeneticVariation BEFREE Moreover, TAS-121 displayed antitumor activity in SW48 (<i>EGFR</i> G719S) and NCI-H1975 (<i>EGFR</i> L858R/T790M) xenograft models, and achieved an objective response in patients with NSCLC with <i>EGFR</i> mutations including G719A mutation. 30872380

2019

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Mutations in the tyrosine kinase domain of the EGFR gene associated with gefitinib response in non-small-cell lung cancer. 16011858

2005

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. 15738541

2005

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. 20479403

2010

dbSNP: rs121913428
rs121913428
0.740 GeneticVariation BEFREE Notably, NGS of CSF was superior to genetic testing of peripheral blood at identifying an uncommon EGFR mutation (G719A) in a patient with NSCLC and leptomeningeal metastases. 31396478

2019

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. 15710947

2005

dbSNP: rs121913428
rs121913428
A 0.740 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913428
rs121913428
C 0.740 CausalMutation CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918

2012