|
rs11071938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in AKT (rs1130214 and rs1130233) and SMAD3 (rs6494633, rs11071938 and rs11632964) have been associated with survival in advanced NSCLC patients treated with EGFR-TKIs.
|
31416579 |
2020 |
|
rs11632964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in AKT (rs1130214 and rs1130233) and SMAD3 (rs6494633, rs11071938 and rs11632964) have been associated with survival in advanced NSCLC patients treated with EGFR-TKIs.
|
31416579 |
2020 |
|
rs13213007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined results of two datasets showed that two independent, potentially functional SNPs (i.e., HDAC2 rs13213007G>A and PPARGC1A rs60571065T>A) were significantly associated with NSCLC overall survival, with a combined hazards ratio (HR) of 1.26 (95% confidence interval (CI), 1.09-1.45; P = .002) and 1.23 (1.04-1.47; P = .017), respectively.
|
31713888 |
2020 |
|
rs2067051
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration.
|
31424642 |
2020 |
|
rs217727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
H19 polymorphism rs2067051 and rs217727 might influence NSCLC susceptibility and the mechanism warrants further exploration.
|
31424642 |
2020 |
|
rs2839698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant association was observed between rs2839698, rs4929984 and NSCLC risk.
|
31424642 |
2020 |
|
rs4929984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no significant association was observed between rs2839698, rs4929984 and NSCLC risk.
|
31424642 |
2020 |
|
rs60571065
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined results of two datasets showed that two independent, potentially functional SNPs (i.e., HDAC2 rs13213007G>A and PPARGC1A rs60571065T>A) were significantly associated with NSCLC overall survival, with a combined hazards ratio (HR) of 1.26 (95% confidence interval (CI), 1.09-1.45; P = .002) and 1.23 (1.04-1.47; P = .017), respectively.
|
31713888 |
2020 |
|
rs1026411
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, polymorphisms in rs1026411 and rs710886 were observed to have significant associations with susceptibility to non-small cell lung cancer (AG vs. GG: odds ratio [OR]<sup>a</sup> = 0.701, <i>p</i>* = 0.020 and AA+AG vs. GG: OR<sup>a</sup> = 0.711 [superscript "a" refers to OR adjusted by age, gender, and smoking], <i>p</i>* = 0.017 [asterisks "*" refers to <i>p</i> adjusted by age, gender, and smoking] for rs1026411; CT vs. TT: OR<sup>a</sup> = 0.723, <i>p</i>* = 0.047 and CC+CT vs. TT: OR<sup>a</sup> = 0.729, <i>p</i>* = 0.038 for rs710886).
|
31464517 |
2019 |
|
rs1046175
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, SFTPB rs7316, rs9752, and PAOX rs1046175 gene polymorphisms affect the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han NSCLC.
|
31016788 |
2019 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our results suggest that ERCC1 rs3212986, XRCC1 rs25487, MDM2 rs1690924, MTR rs1805087, and SLC19A1 rs1051266 gene polymorphisms may significantly act as predictive factors in NSCLC patients treated with platinum-based chemotherapy.
|
29662106 |
2019 |
|
rs1051753269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Newly emergent acquired EGFR exon 18 G724S mutation after resistance of a T790M specific EGFR inhibitor osimertinib in non-small-cell lung cancer: a case report.
|
30588029 |
2019 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that SNP rs10741657 in the CYP2R1 gene was associated with the prognosis of NSCLC, especially in elderly patients and not being treated with chemotherapy.
|
31625015 |
2019 |
|
rs11045585
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequently, we analyzed genetic variants [ABCC10 (rs2125739), ABCB1 (C1236T, C3435T, G2677 T/A), ABCC2 (rs12762549), and SLCO1B3 (rs11045585)] in 69 blood samples of NSCLC patients treated with docetaxel monotherapy.
|
30890141 |
2019 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both maintained T-cell responses in peripheral blood to oncogenic driver mutations - BRAF-N581I in the NSCLC and AKT1-E17K in the CRC - years after treatment initiation.
|
30744692 |
2019 |
|
rs1273957629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fifty-six distinct uncommon <i>EGFR</i> mutations other than L858R, exon19del, exon20ins, or T790M were identified in 18.9% of patients with <i>EGFR</i>-mutant NSCLC.
|
30902917 |
2019 |
|
rs1458974438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KRAS G12D and STK11 mutations confer poor prognoses for patients with KRAS-mutant NSCLC.
|
31200821 |
2019 |
|
rs1732786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that DTX1 rs1732786 is a potential prognostic factor that may have clinical utility in the management of early stage NSCLC.
|
31313037 |
2019 |
|
rs1834481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By genetic model analysis, we found that rs5744256</span> and rs1834481 were associated with a decreased risk of NSCLC under dominant and log-additive models (p < 0.05).
|
31670094 |
2019 |
|
rs1957860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We, therefore, performed a case-control study to investigate the association of seven selected single nucleotide polymorphisms (SNPs), in genes coding for excision repair cross-complimentary group 1 (ERCC1: rs11615, rs3212986, rs2298881), nuclear factor ĸB (NFKB2: rs7897947, rs12769316), bone morphogenetic protein 4 (BMP4: rs1957860), complement receptor 1 (CR1: rs7525160) and del/ins polymorphism in the family hypoxia inducible factor 2 gene (EGLN2: rs10680577), with non-small cell lung cancer (NSCLC) risk.
|
31177178 |
2019 |
|
rs219741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variant genotypes in rs219741 were associated with NSCLC risk in young patients, and the adjusted OR was 1.47 (95%CI: 1.03-2.10, P = 0.033) when compared to the wild genotype.
|
30980423 |
2019 |
|
rs2239895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stratified analysis for age, rs2239895 GC genotype was observed to increase the risk of non-small-cell lung cancer compared with CC genotype (OR 1.562, 95%CI, 1.029-2.371, P = 0.036).
|
31704150 |
2019 |
|
rs2241490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined analysis of the three SNPs related the number of risk alleles (rs2241490-A, rs512932-G and rs8111742-G) to death risk of NSCLC in a locus-dosage mode (P for trend <0.001).
|
30843663 |
2019 |
|
rs2853669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of rs2853669 with telomerase reverse transcriptase (TERT) mRNA level and relative telomere length (RTL) was analysed using resected tumour samples from 250 NSCLC patients.
|
31446212 |
2019 |
|
rs3021094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele 'G' of IL-18 rs5744256 and rs1834481 and IL-10 rs3021094 was correlated with a decreased risk of NSCLC (p < 0.05).
|
31670094 |
2019 |