Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519784
rs1057519784
ALK
0.020 GeneticVariation BEFREE Exploring the crizotinib resistance mechanism of NSCLC with the L1196M mutation using molecular dynamics simulation. 29067524

2017
dbSNP: rs1057519784
rs1057519784
ALK
0.020 GeneticVariation BEFREE Alectinib is a new generation ALK inhibitor with activity against the gatekeeper L1196M mutation that showed remarkable activity in a phase I/II study with echinoderm microtubule associated protein-like 4 (EML4)--anaplastic lymphoma kinase (ALK) non-small cell lung cancer (NSCLC) patients. 24952482

2014