|
rs121913465
|
|
|
0.740 |
GeneticVariation |
BEFREE |
A female patient with advanced NSCLC with a single S768I mutation achieved effectiveness from afatinib after showing no response to gefitinib.
|
29731638 |
2018 |
|
rs121913465
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We used a natural language search program to search our electronic medical record system and every EGFR mutation analysis of patients with NSCLC treated at Mayo Clinic that was performed in our Department of Molecular Genetics to identify patients with EGFR S768I mutation.
|
27211795 |
2016 |
|
rs121913465
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Consistently, afatinib was clinically effective for the treatment of NSCLC harboring G719C and S768I mutations of EGFR.
|
27794398 |
2016 |
|
rs121913465
|
|
T |
0.740 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
rs121913465
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib.
|
20522446 |
2010 |
|
rs121913465
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
We reported a case of non-small cell lung cancer harboring a rare epidermal growth factor somatic mutation, codon 768 AGC > ATC in exon 20 (S768I), who showed a good clinical response to gefitinib.
|
20522446 |
2010 |
|
rs121913465
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Second-line treatments after first-line gefitinib therapy in advanced nonsmall cell lung cancer.
|
19536777 |
2010 |
|
rs121913465
|
|
T |
0.740 |
GeneticVariation |
CLINVAR |
Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.
|
19147750 |
2009 |
|
rs121913465
|
|
T |
0.740 |
GeneticVariation |
CLINVAR |
EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
|
17653080 |
2008 |
|
rs121913465
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification.
|
16863509 |
2006 |
|
rs121913465
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants.
|
16205628 |
2006 |
|
rs121913465
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
High frequency of epidermal growth factor receptor mutations with complex patterns in non-small cell lung cancers related to gefitinib responsiveness in Taiwan.
|
15623594 |
2004 |