With an aim to determine the association of variations in <i>IGF2BP2</i> and <i>IGFBP3</i> genes with risk of non-small-cell lung cancer (NSCLC), <i>IGF2BP2</i> rs1470579 A>C, rs4402960 G>T and <i>IGFBP3</i> rs2270628 C>T, rs3110697 G>A, and rs6953668 G>A polymorphisms were selected and genotyped in 521 NSCLC patients and 1,030 controls.