Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness (IMT), and the ankle-brachial index, in 1188 adults free of cardiovascular disease, randomly selected from the population. 29773421

2019

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE Conversely, the variant T allele of rs11591147 protects carriers from cardiovascular disease susceptibility and lower TC and LDL-C levels in Caucasians. 28606094

2017

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease. 27856457

2017

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE In summary, R46L</span>, I474V, and E670G may be genetic risk factors for cardiovascular disease (CVD) in urban males, rural females, and urban females, respectively. 25899039

2015

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE PCSK9 R46L, lower LDL, and cardiovascular disease risk in familial hypercholesterolemia: a cross-sectional cohort study. 25278291

2014

dbSNP: rs11591147
rs11591147
0.760 GeneticVariation BEFREE Our data support the concept that the rare allele of the R46L SNP at the PCSK9 locus significantly lowers LDL C, but does not greatly reduce CHD risk in an elderly population with a high prevalence of cardiovascular disease. 18262190

2008