Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE Three tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers. 31328431

2019

dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE TLR4 Asp299Gly polymorphism is independently associated with the occurrence of CVDs in HIV-infected patients. 29547441

2018

dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE The results of our study demonstrated that the G allele of the Asp299Gly polymorphism of the TLR4 gene is associated with increased risk of cardiovascular disease and diabetic retinopathy in type 2 diabetes patients. 27321310

2016

dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE Lack of association between TLR4 rs4986790 polymorphism and risk of cardiovascular disease in patients with rheumatoid arthritis. 22360682

2012

dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE The Toll-like receptor (TLR)4 is the major sensor for bacterial lipopolysaccharide and its two common co-segregating polymorphisms, Asp299Gly and Thr399Ile, which occur at a frequency of between 6 and 10%, have been associated with infectious diseases, LPS hypo-responsiveness and cardiovascular disease. 16437123

2006

dbSNP: rs4986790
rs4986790
0.060 GeneticVariation BEFREE We evaluated the TLR4 D299G polymorphism among 695 individuals with incident myocardial infarction (MI) or stroke and among 695 age- and smoking-matched individuals who remained free of reported cardiovascular disease during follow-up within the Physicians' Health Study. 15576653

2005