Our meta-analysis results strongly suggest that the ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G</span>) are not associated with CVD risk.
The two most frequently studied polymorphisms located in ESR1 are often identified by their restriction endonucleases Pvull (rs2234693) and Xbal (rs9340799). ln this review, we have evaluated and summarized the results of studies involving rs2234693 and rs9340799 and clustered risk factors accompanying development of CVD.