Gene: APOB ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1367117
rs1367117
APOB
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019
dbSNP: rs5742904
rs5742904
APOB
0.020 GeneticVariation BEFREE Because FDB is one of the independent causes of early onset CHD, the R3500Q mutation should be considered in families with a high frequency of cardiovascular diseases. 11137107

2001
dbSNP: rs5742904
rs5742904
APOB
0.020 GeneticVariation BEFREE Familial defective apolipoprotein B-100, a dominantly inherited form of hypercholesterolemia caused by a single Arg3500Gln mutation, is silent in childhood but may confer a high risk of cardiovascular disease in adulthood. 11568510

2001
dbSNP: rs693
rs693
APOB
0.010 GeneticVariation BEFREE Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease. 28992985

2018
dbSNP: rs676210
rs676210
APOB
0.010 GeneticVariation BEFREE The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography. 24681816

2014
dbSNP: rs1042034
rs1042034
APOB
0.010 GeneticVariation BEFREE We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, to determine whether aging-related processes in changing environments can substantially impact the role of lipid-related genes discovered in candidate gene (the apolipoprotein E (APOE) e2/3/4 polymorphism) and genome-wide (the APOB rs1042034 (C/T)) studies, in regulation of total cholesterol (TC) and onset of cardiovascular disease (CVD). 23320904

2013