|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
We analyzed the association of the PCSK9 rs11591147 single-nucleotide polymorphism with lipid levels, intima-media thickness (IMT), and the ankle-brachial index, in 1188 adults free of cardiovascular disease, randomly selected from the population.
|
29773421 |
2019 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Conversely, the variant T allele of rs11591147 protects carriers from cardiovascular disease susceptibility and lower TC and LDL-C levels in Caucasians.
|
28606094 |
2017 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Carriers of the PCSK9 (proprotein convertase subtilisin/kexin 9) R46L genetic variant (rs11591147) are characterized by low levels of low-density lipoprotein cholesterol and a decreased risk of cardiovascular disease.
|
27856457 |
2017 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
In summary, R46L</span>, I474V, and E670G may be genetic risk factors for cardiovascular disease (CVD) in urban males, rural females, and urban females, respectively.
|
25899039 |
2015 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
PCSK9 R46L, lower LDL, and cardiovascular disease risk in familial hypercholesterolemia: a cross-sectional cohort study.
|
25278291 |
2014 |
|
rs11591147
|
|
|
0.760 |
GeneticVariation |
BEFREE |
Our data support the concept that the rare allele of the R46L SNP at the PCSK9 locus significantly lowers LDL C, but does not greatly reduce CHD risk in an elderly population with a high prevalence of cardiovascular disease.
|
18262190 |
2008 |
|
rs1801253
|
|
|
0.740 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1801253
|
|
|
0.740 |
GeneticVariation |
BEFREE |
We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders.
|
24982877 |
2014 |
|
rs1801253
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The Arg389Gly polymorphism of the ADRB1 gene may be a worthy biological marker to predict the risk of developing cardiovascular diseases given a high-risk atherogenic index.
|
24371822 |
2013 |
|
rs1801253
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Various studies suggest an association between beta(1)-adrenoceptor gene polymorphisms (Ser49Gly and Arg389Gly) and cardiovascular disorders, including hypertension, cardiomyopathy and congestive heart failure.2.
|
19673943 |
2009 |
|
rs1801253
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The human beta(1)-adrenergic receptor, an important therapeutic target in cardiovascular diseases, has 2 common functional polymorphisms (Ser49Gly and Gly389Arg).
|
16815314 |
2006 |
|
rs3184504
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A SH2B3 missense variant (rs3184504) is associated with cardiovascular diseases plus breast, colorectal and lung cancers, with highly correlated variants across the ATXN2/SH2B3/BRAP locus linked to parental age at death, suggesting a geroscience common mechanism of aging and disease.
|
31428775 |
2019 |
|
rs3184504
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs3184504
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We found that BP, CAD and IS shared for phosSNPs in loci that contain functional genes involve in cardiovascular diseases, e.g., rs11556924 (ZC3HC1), rs1971819 (ICA1L), rs3184504 (SH2B3), rs3739998 (JCAD), rs903160 (SMG6).
|
31456518 |
2019 |
|
rs1229984
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs7412
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs964184
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs10911021
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Over a median of 9.6 years of follow-up, the risk (C) allele for GLUL r</span>s10911021 was significantly associated with the primary composite end point of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina among individuals with no history of cardiovascular disease (CVD) at baseline using additive genetic models (hazard ratio 1.17 [95% CI 1.01-1.36]; P = 0.032).
|
26395743 |
2016 |
|
rs7412
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A total of nine gene variants/polymorphisms - F5 (Leiden - R5 06Q, rs6025), F2 (20210G > A, rs1799963), F13A1 (V34L, rs5985), MTHFR (677C > T - A222V, rs1801133), MTHFR (1298A > C - E429A, rs1801131), FGB (-455G > A -c.-463G > A; rs1800790), SERPINE1 (PAI14G/5G - rs1799889), ACE (ACE I/D, rs1799752), ITGB3 (GPIIIa L33P, rs5918) and the APOE E2/E3/E4 alleles (rs7412, rs429358) - were genotyped in 200 newly diagnosed ischemic stroke (IS) patients, 165 patients with ischemic coronary heart disease (CHD) and 159 controls with no cerebroor cardiovascular disease (non-CVD).
|
27629735 |
2016 |
|
rs1229984
|
|
|
0.710 |
GeneticVariation |
BEFREE |
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.
|
25011450 |
2014 |
|
rs688
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In a previous study, analysis of the genetic LDLR variant rs688 provided evidence suggesting that genetic polymorphisms of rs688 are associated with thrombotic cardiovascular diseases.
|
24295502 |
2014 |
|
rs10911021
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.
|
23982368 |
2013 |
|
rs964184
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis.
|
24131021 |
2013 |
|
rs1047964
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
Further, rs1047964 in BACE1 appeared to be associated with CVD death among women with any migraine (OR = 4.67; 95% CI 2.53-8.62; p = 8.0×10(-7)).
|
21779381 |
2011 |