|
rs6822844
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We found that the minor allele T of both rs6822844 (T vs G, OR = 0.72, 95%CI = 0.67-0.78, P < 0.001) and rs6840978 (T vs C, OR = 0.76, 95%CI = 0.71-0.83, P < 0.001) in IL2/IL21 significantly decreased the risk of CD.
|
26535636 |
2015 |
|
rs6822844
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We detected significant associations of rs6822844 with SLE (P = 0.008), type 1 DM (P = 0.014), RA (P = 0.019), and primary SS (P = 0.033) but not with BD (P = 0.34) or CD (P = 0.98).
|
20112382 |
2010 |
|
rs6822844
|
|
C |
0.840 |
GeneticVariation |
GWASDB |
Newly identified genetic risk variants for celiac disease related to the immune response.
|
18311140 |
2008 |
|
rs6822844
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Newly identified genetic risk variants for celiac disease related to the immune response.
|
18311140 |
2008 |
|
rs6822844
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We could confirm significant association between the polymorphisms rs13119723 A>G and rs6822844 G>T located in the KIAA1109/Tenr/IL2/IL21 region and CD (P-value 0.001 and 0.002, respectively).
|
18418394 |
2008 |
|
rs6822844
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
|
17558408 |
2007 |
|
rs6822844
|
|
G |
0.840 |
GeneticVariation |
GWASCAT |
We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
|
17558408 |
2007 |
|
rs6822844
|
|
G |
0.840 |
GeneticVariation |
GWASDB |
We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.
|
17558408 |
2007 |
|
rs917997
|
|
|
0.830 |
GeneticVariation |
BEFREE |
This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations.
|
26289103 |
2015 |
|
rs917997
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Prior reports link rs917997 allele A with protection from T1D, and conversely with susceptibility to Celiac disease.
|
23891168 |
2013 |
|
rs917997
|
|
A |
0.830 |
GeneticVariation |
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
rs917997
|
|
A |
0.830 |
GeneticVariation |
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
rs917997
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In this study, two previously indicated risk variants at the IL18RAP locus (rs13015714 and rs917997) were tested for genetic association in 1638 cases with coeliac disease and 1385 control individuals from the Finnish, Hungarian and Italian populations.
|
19103669 |
2009 |
|
rs17810546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Celiac disease associated SNP rs17810546 is located in a gene silencing region.
|
31726085 |
2020 |
|
rs17810546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The available data indicated the minor allele C of rs2816316 was negatively associated with CD (C vs. A: OR = 0.77, 95% CI = 0.74-0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31-1.43).
|
27043536 |
2016 |
|
rs17810546
|
|
G |
0.820 |
GeneticVariation |
GWASCAT |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
rs17810546
|
|
G |
0.820 |
GeneticVariation |
GWASDB |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
rs17810546
|
|
G |
0.820 |
GeneticVariation |
GWASDB |
Newly identified genetic risk variants for celiac disease related to the immune response.
|
18311140 |
2008 |
|
rs17810546
|
|
G |
0.820 |
GeneticVariation |
GWASCAT |
Newly identified genetic risk variants for celiac disease related to the immune response.
|
18311140 |
2008 |
|
rs2816316
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The available data indicated the minor allele C of rs2816316 was negatively associated with CD</span> (C vs. A: OR = 0.77, 95% CI = 0.74-0.80), and a positive association was found for the minor allele G of rs17810546 (G vs. A: OR = 1.37, 95% CI = 1.31-1.43).
|
27043536 |
2016 |
|
rs3184504
|
|
|
0.810 |
GeneticVariation |
BEFREE |
However, the minor allele A of rs3184504 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in SH2B3 significantly increased CD susceptibility.
|
26535636 |
2015 |
|
rs6441961
|
|
|
0.810 |
GeneticVariation |
BEFREE |
This meta-analysis provides robust estimates that IL18RAP rs917997 and CCR3 rs6441961 are potential risk factors for celiac disease in European populations.
|
26289103 |
2015 |
|
rs1738074
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
|
24999842 |
2014 |
|
rs2762051
|
|
|
0.810 |
GeneticVariation |
BEFREE |
These four variants are implicated in complex phenotypes such as ulcerative colitis and AIDS progression disease (rs10491434), Celiac disease (rs2762051), Crohn's disease, IgA nephropathy and early-onset inflammatory bowel disease (rs713875) and height (rs6569648).
|
24911414 |
2014 |
|
rs6441961
|
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
|
24999842 |
2014 |