rs2516448
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The cGAS-STING pathway in innate immunity plays an important role in protecting against HPV infection.Chen et al. described that the rs2516448 SNP in the MHC locus may affect susceptibility to cervical cancer, a finding that we attempted to replicate in a Chinese population.
|
27705945 |
2016 |
rs2516448
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
rs9277952
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population.
|
24743517 |
2014 |
rs9277952
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
rs1195571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the individuals older than 43, rs4604006 (VEGF-C) was related to an increased cervical cancer risk under codominant model (p = .035), and rs12646659 was significantly associated with a reduced cervical cancer risk in allele, dominant, log-additive models (allele: p = .028; codominant: p = .037; log-additive: p = .037) However, there were no significant correlation of rs1000611 (VEGFR-2) and rs1195571 (VEGFR-3) with cervical cancer risk in Chinese Uygur population.
|
31478352 |
2019 |
rs180082
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis has shown that there is a lack of association of the Fas rs180082 polymorphisms with cervical cancer susceptibility.
|
23865866 |
2013 |
rs2808630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The four most common single nucleotide gene polymorphisms CRP1919 (rs1417938), CRP2667 (rs1800947), CRP3872 (rs1205), and CRP5237 (rs2808630) were evaluated in 178 patients with cervical cancer.
|
21737650 |
2011 |
rs2844511
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A statistically significant association was observed between single nucleotide polymorphism (SNP) CHR6 rs2844511 and CC risk: the OR for carriers of the GA or GG genotypes was 0.70 (95% CI: 0.43-1.14) and 0.61 (95% CI: 0.38-0.98), respectively, relative to carriers of AA genotype (p-value for trend 0.03).
|
28505207 |
2017 |
rs4769793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, these findings suggested that STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women.
|
21668356 |
2011 |
rs8067378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
rs1800682
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans.
|
24114012 |
2014 |
rs1800682
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms.
|
27790710 |
2017 |
rs2234767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms.
|
27790710 |
2017 |
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, RAGE SNPs rs1800624 was associated with some clinicopathological variables in cervical cancer.
|
30410591 |
2018 |
rs9302648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the SNPs after stratification based on CC clinical stage and subtype revealed that rs1048512, rs6659346, rs217727, rs9931702, and rs9302648 were associated with CC risk in clinical stages I-II; rs2862833, rs2732044, rs1030389, and rs1045935 were associated with CC risk in clinical stages III-IV; and rs217727, rs9931702, and rs9302648 were associated with CC risk in squamous carcinomas.
|
27765929 |
2016 |
rs9931702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the SNPs after stratification based on CC clinical stage and subtype revealed that rs1048512, rs6659346, rs217727, rs9931702, and rs9302648 were associated with CC risk in clinical stages I-II; rs2862833, rs2732044, rs1030389, and rs1045935 were associated with CC risk in clinical stages III-IV; and rs217727, rs9931702, and rs9302648 were associated with CC risk in squamous carcinomas.
|
27765929 |
2016 |
rs5757465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a polymorphic locus rs5757465 on exon 3 of APOBEC3G in Uygur women, and this rare CC type was a risk factor for cervical lesions and cervical cancer (OR=3.714, 95%CI: 1.916-7.202, p<0.05).
|
31527570 |
2019 |
rs807183
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, our results indicate that single nucleotide polymorphisms (SNPs) of autophagy-related protein 4 (ATG4), including rs4036579, rs5973822, rs807181, rs807182 and rs807183, have a significant relationship with cervical cancer risk.
|
29435029 |
2018 |
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study to evaluate the role of ATM G5557A and P53BP1 C1236G polymorphisms in cervical cancer susceptibility.
|
22200742 |
2012 |
rs3744935
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, rs3744935 in BCL2 was associated with CC in the allele and codominant models.
|
27677077 |
2016 |
rs799917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that BRCA1 rs799917 polymorphism may contribute to the risk of cervical cancer in this Chinese population, and further validation in other populations are warranted.
|
19482343 |
2009 |
rs11079454
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To evaluate the association between gene variations in BRIP1 (BRCA1-interacting protein 1) and the risk of cervical cancer, we examined eight single nucleotide polymorphisms (SNPs: rs2048718, rs12937080, rs4988344, rs6504074, rs4988345, rs4986764, rs4986763, and rs11079454) in the BRIP1 gene in cervical tissue from a Chinese population using the MassARRAY system.
|
23473757 |
2013 |
rs11079454
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results provide evidence of the negative association of p21 rs1801270 polymorphism, as well as BRIP1 rs2048718 and rs11079454 polymorphisms, with CC risk.
|
27415837 |
2016 |
rs2048718
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (<i>P</i> < 0.05).
|
29466248 |
2018 |
rs2048718
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also found a negative association with the rs2048718 BRIP1 polymorphism dominant inheritance model (T/C+C/C) and CC (pooled OR = 0.83; 95%CI: 0.70-0.98; p = 0.03), as well as with the rs11079454 BRIP1 polymorphism recessive inheritance model and CC (pooled OR = 0.79; 95%CI: 0.63-0.99; p = 0.04).
|
27415837 |
2016 |