|
rs887829
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Indeed, this is the first report that interested in the study of polymorphisms in genes encoded for enzymes involved in the bilirubin metabolism: rs 4149056 of SLCO1B1 and rs4149000 of SLCO1A2 in combination with rs8175347 and rs887829 of UGT1A1 in order to find a correlation between the polymorphisms studied and the presence of gallstones in a population of sickle cell anemia (SCA) pediatric Tunisians.
|
26146896 |
2016 |
|
rs887829
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
|
22558097 |
2012 |
|
rs887829
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
|
22558097 |
2012 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In retrospective controlled study, we determined D19H polymorphism of ABCG8 gene, genetic variation at Niemann-Pick C1-like 1 (NPC1L1) gene locus (rs41279633, rs17655652, rs2072183, rs217434 and rs2073548), and serum cholesterol, noncholesterol sterols and lipids in children affected by gallstones decades later (n = 66) and controls (n = 126).
|
29764733 |
2018 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Among individuals of African American and Hispanic American ancestry, rs11887534 and rs4245791 were associated positively with gallstone disease risk, whereas the association for the rs1260326 variant was inverse.
|
27094239 |
2016 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study showed strong association of D19H polymorphism with gallstone disease.
|
24498041 |
2014 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Mutational analysis of ABCB4, screening for copy number variations by multiplex ligation-dependent probe amplification, genotyping for low expression allele c.1331T>C of ABCB11 and genotyping for variation c.55G>C in ABCG8 previously associated with cholesterol gallstones in adults was performed in 35 pediatric subjects with idiopathic gallstones who fulfilled the clinical criteria for low phospholipid-associated cholelithiasis syndrome (LPAC, OMIM #600803) and in 5 young females with suspected LPAC and their families (5 probands, 15 additional family members).
|
24914347 |
2014 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Both gallstone disease and p.D19H of ABCG8 are associated with diminished cholesterol absorption.
|
23406058 |
2013 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
ABCG5 rs6756629 is in strong linkage disequilibrium with rs11887534 (D19H), a variant previously associated with gallstone disease risk in populations of European-descent.
|
24256507 |
2013 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
ABCG8-D19H is a predictor of gallstone recurrence, a major long term postoperative biliary complication.
|
22869156 |
2013 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Carriers of the CG genotype of ABCG8 rs118</span>87534 had higher risk of bi</span>liary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this general population cohort, ABCG8 D19H genotype was an important predictor of both symptomatic gallstone disease and biliary cancer.
|
21274884 |
2011 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Carriers of the DH genotype and H allele of the ABCG8 D19H polymorphism harbor a higher risk for gallstone susceptibility in the northern Indian population.
|
21039838 |
2010 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In our study we investigated the contribution of heterozygosity for common variations considered either potentially pathogenic or susceptibility alleles for cholesterol cholelithiasis in adults (c.523A>G (p.Thr175Ala) and c.1954A>G (p.Arg652Gly) in ABCB4, c.1331T>C (p.Val444Ala) in ABCB11 and c.55 G>C (p.Asp19His) in ABCG8) to the aetiology of paediatric idiopathic gallstone disease.
|
20163776 |
2010 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our study confirms the ABCG8 D19H genotype as a major risk factor for gallstone disease.
|
20497293 |
2010 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A common genetic polymorphism D19H of ABCG8 associated with gallstone disease may be causatively related to the genetic predisposition of GBC.
|
19018975 |
2009 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Carriers of ABCG5 604Q or ABCG8 D19H polymorphisms have an increased risk of gallstone disease independent of age, sex and body mass index.
|
18457353 |
2008 |
|
rs11887534
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
|
17632509 |
2007 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Consistent with the mouse model, heterozygosity for the lithogenic ABCG8 allele was associated with gallstones in humans; 21.4% of gallstone patients carried the heterozygous D19H genotype, compared with 8.6% of controls (OR = 2.954; P = 0.026).
|
17626266 |
2007 |
|
rs11887534
|
|
|
0.800 |
GeneticVariation |
BEFREE |
To investigate a possible association between transporter gene polymorphism and gallstone formation, we examined five common polymorphisms in the ABCG5 (Q604E) and ABCG8 (D19H, Y54C, T400K, A632V) genes in patients with gallstone disease (GS).
|
17612515 |
2007 |
|
rs4245791
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Among individuals of African American and Hispanic American ancestry, rs11887534 and rs4245791 were associated positively with gallstone disease risk, whereas the association for the rs1260326 variant was inverse.
|
27094239 |
2016 |
|
rs4245791
|
|
|
0.710 |
GeneticVariation |
GWASDB |
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
|
17632509 |
2007 |
|
rs10094715
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
|
17632509 |
2007 |
|
rs1011770
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
|
17632509 |
2007 |
|
rs10888095
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
|
17632509 |
2007 |