Of note, the synergic effects of the genotypes and chromosomal abnormality all tallied with the sub-multiplication model (OR<sub>chromosome</sub> × OR<sub>SNP</sub> > OR<sub>chromosome+SNP</sub>), while rs2232365 GG and chromosomal aberration impacted the RSA risk in a super-multiplicative way that OR<sub>chromosome</sub> × OR<sub>SNP</sub> < OR<sub>chromosome+SNP</sub>.