|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
|
rs34637584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether human LRRK2 with G2019S mutation causes hippocampus-dependent cognitive deficits in mice.
|
28487191 |
2017 |
|
rs2230288
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The discovery that E326K negatively impacts cognitive performance approximately doubles the proportion of PD patients we now recognize are at risk for more severe GBA-related cognitive deficits.
|
26296077 |
2016 |
|
rs34637584
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice.
|
26282470 |
2015 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we examined the effect of obovatol on cognitive deficits in two separate AD models: (i) mice that received intracerebroventricular (i.c.v.) infusion of Aβ(1-42) (2.0 μg/mouse) and (ii) Tg2576 mice-expressing mutant human amyloid precursor protein (K670N, M671L).
|
22212065 |
2012 |
|
rs371425292
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs572842823
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both synaptic and cognitive deficits are reproduced in mice double transgenic for amyloid precursor protein (AA substitution K670N,M671L) and presenilin-1 (AA substitution M146V).
|
15578094 |
2004 |
|
rs10748842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NRG3 rs10748842 may not confer susceptibility to schizophrenia, but may be more closely associated with cognitive deficit, especially attention performance in chronic schizophrenia.
|
31753594 |
2020 |
|
rs104893878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TCE or TaClo did not appear to lead to acceleration of motor or cognitive deficits in either wild type or A30P mutant mice, potentially because of the modest reductions of DA neuronal number in the SNpc.
|
31422098 |
2019 |
|
rs11136000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11136000 genotypes in combination with HDL levels and knowledge about diabetes background may be used as a predictive medicine tool for cognitive disorders.
|
30560405 |
2019 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show that rs16969968 on CHRNA5 is tightly linked to genetic susceptibility, psychotic symptoms and cognitive deficits in SCZ in an early-onset Chinese population, suggesting that CHRNA5 may play an important role in the etiology of SCZ.
|
30366711 |
2019 |
|
rs429358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs75548401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs761715536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients.
|
31505070 |
2019 |
|
rs104893877
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we first provided evidence that RV treatment alleviated motor and cognitive deficits in the A53T α-synuclein mouse model of PD in a dose-dependent manner.
|
30462117 |
2018 |
|
rs1108580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
rs121909668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.
|
30273830 |
2018 |
|
rs1611115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examines the association of plasma DβH (pDβH) activity, DBH gene polymorphisms (-1021C>T, rs1611115 and 444G>A, rs1108580) and cognitive deficits in Han Chinese patients with schizophrenia.
|
28647493 |
2018 |
|
rs63751273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we studied the effects of P301L hTau transduction in the medial EC (MEC) of mice on tau phosphorylation and accumulation, and cognitive deficit.
|
28634382 |
2017 |