Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2275913
rs2275913
IL17A
0.050 GeneticVariation BEFREE Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). 24776844

2014
dbSNP: rs2275913
rs2275913
IL17A
0.050 GeneticVariation BEFREE Our results suggest that IL17A polymorphisms (both rs2275913 and rs3748067) influence the susceptibility to and pathophysiological features of UC, coordinately. 22955700

2013
dbSNP: rs2275913
rs2275913
IL17A
0.050 GeneticVariation BEFREE The IL17A (rs2275913, G-197A) variant had a weak association with the severity of UC. 23652560

2013
dbSNP: rs2275913
rs2275913
IL17A
0.050 GeneticVariation BEFREE The single nucleotide polymorphism (SNP), rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis. 22028838

2011
dbSNP: rs2275913
rs2275913
IL17A
0.050 GeneticVariation BEFREE We investigated the association between ulcerative colitis (UC) and polymorphisms of IL-17A (rs2275913, G-197A) and IL-17F (rs763780, 7488T/C) genes. 17828618

2008