Gene: TP53 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934576
rs28934576
TP53
T 0.740 CausalMutation CLINVAR

dbSNP: rs11540652
rs11540652
TP53
T 0.710 CausalMutation CLINVAR

dbSNP: rs1131691003
rs1131691003
TP53
A 0.700 CausalMutation CLINVAR

dbSNP: rs1131691042
rs1131691042
TP53
T 0.700 CausalMutation CLINVAR

dbSNP: rs121912651
rs121912651
TP53
C 0.700 GeneticVariation CLINVAR

dbSNP: rs28934578
rs28934578
TP53
T 0.700 CausalMutation CLINVAR

dbSNP: rs55832599
rs55832599
TP53
A 0.700 GeneticVariation CLINVAR

dbSNP: rs28934575
rs28934575
TP53
0.010 GeneticVariation BEFREE The other three mutations (Arg175Gly, DeltaPro190, and Gly245Ser) have been found in colorectal carcinomas, the last commonly. 12010886

2002
dbSNP: rs879253942
rs879253942
TP53
0.010 GeneticVariation BEFREE Females who were heterozygous or homozygous for the C677T MTHFR polymorphism were at increased risk of developing CIMP+ CRC (odds ratio 2.17, 95% confidence interval 1.03-4.57; p=0.037). 12427779

2002
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors. 16353134

2006
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. 17374954

2006
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45). 16721787

2006
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45). 16721787

2006
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. 17374954

2006
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors. 16353134

2006
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors. 16353134

2006
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. 17374954

2006
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45). 16721787

2006
dbSNP: rs1131691029
rs1131691029
TP53
0.010 GeneticVariation BEFREE In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism. 16489531

2006
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers. 17599946

2007
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use. 17622940

2007
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients. 17224235

2007
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use. 17622940

2007
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers. 17599946

2007
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients. 17224235

2007