Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE We therefore investigated the anti-tumor properties of a gold(I) <i>N</i>-heterocyclic carbene (NHC) complex-termed MC3-in human colorectal cancer (CRC) cell lines encompassing three different p53 variations: HCT116 wild-type (WT), HCT116 p53<sup>-/-</sup>, and HT-29 (mutant; R273H). 31231607

2019

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE Finally, lnc273-31 and lnc273-34 were significantly highly expressed in CRC tissues with p53-R273H mutation compared to those with wildtype p53. 31455383

2019

dbSNP: rs28934576
rs28934576
T 0.740 CausalMutation CLINVAR

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE Our findings indicate the R270H/R273H p53 mutant protein does not manifest definite GOF biological effects in mouse and human CRCs, suggesting possible GOF effects of mutant p53 in cancer phenotypes are likely allele-specific and/or context-dependent. 31148594

2019

dbSNP: rs28934576
rs28934576
0.740 GeneticVariation BEFREE The CRC colorectal cancer (CRC) cell lines HCT116 wild-type (wt), HCT116 p53-/-, and HT-29 (mutant; R273H) were employed, covering three different p53 variations. 28618116

2017

dbSNP: rs11540652
rs11540652
T 0.710 CausalMutation CLINVAR

dbSNP: rs11540652
rs11540652
0.710 GeneticVariation BEFREE We show that the most common mutp53 allele R248Q (p53<sup>Q</sup>) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displacing the phosphatase SHP2. 30107178

2018

dbSNP: rs1131691003
rs1131691003
A 0.700 CausalMutation CLINVAR

dbSNP: rs1131691042
rs1131691042
T 0.700 CausalMutation CLINVAR

dbSNP: rs121912651
rs121912651
C 0.700 GeneticVariation CLINVAR

dbSNP: rs28934578
rs28934578
T 0.700 CausalMutation CLINVAR

dbSNP: rs55832599
rs55832599
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P TP53 polymorphism alone, suggesting an inter-relationship with other genetic and/or environmental factors. 16353134

2006

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men. 30316510

2018

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers. 17599946

2007

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis. 29872345

2018

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population. 22393962

2011

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in carcinogenesis of CRC in Chinese, especially in smokers, and this kind of interaction is associated with onset age of CRC. 22744426

2012

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Our data suggest that R72P variant seems to be associated with high risk for development of CRC but carries low risk for development of UC. 20309662

2010

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms and the risk of CRC. 23183747

2013

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Unexpectedly no significant association was found between this potential marker TP53 Arg72Pro and CRC (p > 0.05). 25537146

2015

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE We did not identify an association between TP53 rs1042522 and colorectal cancer. 20615891

2010

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC. 24337371

2014

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma. 17374954

2006

dbSNP: rs1042522
rs1042522
0.100 GeneticVariation BEFREE We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use. 17622940

2007