|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827.
|
29084532 |
2017 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
|
17934461 |
2007 |
|
rs4464148
|
|
|
0.780 |
GeneticVariation |
GWASDB |
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
|
17934461 |
2007 |
|
rs7226855
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
|
25990418 |
2015 |
|
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs11874392
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Additionally, gene-smoking interactions for rs11874392, rs10988706 and rs6478972 were also found to enhance the risk of CRC at both stages, with P for multiplicative interaction equal to 1.162×10(-6), 8.574×10(-8) and 9.410×10(-8) in combined analyses, respectively.
|
23275154 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the European CRC-susceptibility SNPs, rs4939827 in SMAD7 was associated with a significant decreased risk of Korean CRC (age-/gender-adjusted odds ratio [95% confidence interval]: additive model, 0.67 [95% CI, 0.47-0.95]; dominant model, 0.59 [95% CI, 0.39-0.91]). rs4779584 and rs10795668 were associated with CRC risk in females and males, respectively.
|
23875689 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer.
|
23560096 |
2013 |
|
rs11874392
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Among the population-based families, both SNPs rs12953717 (odds ratio, 1.29; 95% confidence interval, 1.12-1.49), and rs11874392 (odds ratio, 0.80; 95% confidence interval, 0.70-0.92) were associated with risk of colorectal cancer.
|
23560096 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those with CRC, the minor allele (G) in rs4939827 was significantly associated with poorer overall survival (hazards ratio, 1.20; 95% CI, 1.02-1.42).
|
23104301 |
2013 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those without distant disease at diagnosis, CRC-specific survival differed by genotype only for NSAID users: each minor allele of rs4939827 was associated with worse survival [hazard ratio (HR) = 2.67, 95% confidence interval (CI): 1.33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94).
|
21910156 |
2011 |
|
rs4464148
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Among those without distant disease at diagnosis, CRC-specific survival differed by genotype only for NSAID users: each minor allele of rs4939827 was associated with worse survival [hazard ratio (HR) = 2.67, 95% confidence interval (CI): 1.33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94).
|
21910156 |
2011 |
|
rs11874392
|
|
|
0.730 |
GeneticVariation |
BEFREE |
As partial validation of our approach, a known CRC risk variant in SMAD7 (in both the TGF-β and WNT pathways: rs11874392) was associated with CRC risk in our data.
|
29986644 |
2018 |
|
rs7226855
|
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
|
31089142 |
2019 |
|
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC).
|
25640388 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas.
|
29228715 |
2017 |
|
rs7229639
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Besides, seven SNPs (rs10808555, rs7014346, rs7837328, rs704017, rs11196172, rs4779584, and rs7229639) were significantly associated with CRC, and another one SNP rs11903757 was over-represented in CRA compared with controls.
|
27769063 |
2016 |
|
rs11874392
|
|
A |
0.730 |
GeneticVariation |
GWASCAT |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
rs6507874
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
|
rs16950113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight miRSNPs (rs1804191, rs397768, rs41116 in APC; rs1137918, s227091, rs4585 in ATM; rs712, rs1137282, rs61764370 in KRAS; rs8674 in PARP1 and rs16950113 in SMAD7) were tested for their association with CRC risk in a case-control study (1111 cases and 1469 healthy controls).
|
29048575 |
2017 |
|
rs4464148
|
|
|
0.780 |
GeneticVariation |
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For SMAD7 gene, rs4939827 and rs4464148 are risk factors for CRC among Caucasian whereas rs12953717 could elevate the susceptibility to CRC in both Caucasian and Asian.
|
26579801 |
2015 |
|
rs12953717
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For SNPs on 18q21 (rs12953717 and rs4464148) and 20q13 (rs4925386), alleles that correlate with higher risk for the development of CRC are associated with shorter disease free survival (DFS).
|
29119627 |
2018 |