|
rs1064795841
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings may shed light on the mechanism of AR in CRC, namely, that the PT harbored the same mutations as the AR and the lesions in both cases harbored the KRAS G13D mutation.
|
30896620 |
2019 |
|
rs1427471466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |
|
rs746504075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants that disrupted RPS20 were detected in a Finnish family with early-onset CRC (p.Val50SerfsTer23), a 39-year old individual with metachronous CRC (p.Leu61GlufsTer11 mutation), and a 41-year-old individual with CRC (missense p.Val54Leu), but not in controls.
|
27713038 |
2017 |
|
rs12947788
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study results revealed that the rs1042522 genotype with the C allele and the rs12947788 genotype with the T allele in TP53 were associated with a decreased CRC risk in patients with Lynch syndrome in Taiwan.
|
27907203 |
2016 |
|
rs587780071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study is the first study that investigates the relationship among variants of CDKN2 p16 540 C>G, 580 C>T, and MDM2 SNP309 T>G risk of CRC and the development and progression in the Turkish population.
|
23777425 |
2013 |
|
rs1131691029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we evaluated the association between colorectal cancer and specific tumor mutations and the Pro12Ala (P12A) PPARgamma polymorphism.
|
16489531 |
2006 |
|
rs28934575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other three mutations (Arg175Gly, DeltaPro190, and Gly245Ser) have been found in colorectal carcinomas, the last commonly.
|
12010886 |
2002 |
|
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Females who were heterozygous or homozygous for the C677T MTHFR polymorphism were at increased risk of developing CIMP+ CRC (odds ratio 2.17, 95% confidence interval 1.03-4.57; p=0.037).
|
12427779 |
2002 |
|
rs1800371
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrast, all genetic models showed no statistical association of TP53 Pro47Ser polymorphism among CRC patients compared with healthy controls.
|
29560751 |
2019 |
|
rs1800371
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri population.
|
20449797 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study replicated an association of <i>CCAT2</i> rs6983267 with CRC and an interaction between <i>TP53</i> rs1042522 and NSAID in relation to CRC.
|
30841568 |
2019 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
|
rs878854066
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study results revealed that the rs1042522 genotype with the C allele and the rs12947788 genotype with the T allele in TP53 were associated with a decreased CRC risk in patients with Lynch syndrome in Taiwan.
|
27907203 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly no significant association was found between this potential marker TP53 Arg72Pro and CRC (p > 0.05).
|
25537146 |
2015 |